Thymoma – disease of many faces
Authors:
Kateřina Pokorná; Vladimír Kojecký
Authors‘ workplace:
Interní oddělení, Nemocnice Tomáše Bati ve Zlíně
Published in:
Vnitř Lék 2021; 67(4): 240-243
Category:
Case reports
Overview
A thymoma belongs to rather rare tumors, although it holds the first place among primary mediastinal tumors in adults. The biological characteristics of thymomas are considerably divergent. The tumors are usually asymptomatic at the begining, later due to a local spread, symptoms from the infiltration or compression of adjacent structures arise, they metastasize rarely. Thymomas are often associated with various autoimmune or endocrinologic diseases. The authors present case of the patient with less common paraneoplasia – autoimmune hemolytic anemia (AIHA). Main strategy of treatment thymom with AIHA isn´t clear. The most important seems to be the early started corticotherapy. Achieving remission of secondary AIHA has importace in following therapy of thymoma – surgical resection or chemotherapy. Thymectomy has positive effect on the course of associated paraneoplastic syndromes and prognosis in general.
Keywords:
autoimunne hemolytic anemia – paraneoplastic symptom – thymoma – warm antibodies
Sources
1. Büchler T et al. Speciální onkologie. Maxdorf: Praha 2017: 33–37, ISBN 978-80-7345-539-2.
2. Souček M et al. Vnitřní lékařství, 1. díl. In: Souček M, Špinar J, Vorlíček J (eds) et al. Grada: Praha 2011: 572–573, ISBN 978-80-247-2110-1.
3. Rajan A, Zhao C. Deciphering the biology of thymic epithelial tumors. Mediastinum. 2019; 3: 36. Dostupné z DOI:.
4. Adam Z, Krejčí M, Vorlíček J et al. Speciální onkologie. Příznaky, diagnostika a léčba maligních chorob. Galén: Praha 2010: 49–53, ISBN 978-80-7262-648-9.
5. Sun L, Li H, Luo H et al. Thymic epithelial cell development and its dysfunction in human diseases. Biomed Res Int. 2014; 2014: 206929. Dostupné z DOI:.
6. Alexandropoulos K, Bonito AJ, Weinstein EG et al. Medullary thymic epithelial cells and central tolerance in autoimmune hepatitis development: novel perspective from a new mouse model. Int J Mol Sci. 2015; 16(1): 1980–2000. Published 2015 Jan16. Dostupné z DOI:.
7. Shelly S, Agmon-Levin N, Altman A et al. Thymoma and autoimmunity. Cell Mol Immunol. 2011; 8(3): 199–202. Dostupné z DOI:.
8. Blum TG, Misch D, Kollmeier J et al. Autoimmune disorders and paraneoplastic syndromes in thymoma. J Thorac Dis. 2020;12(12):7571-7590. Dostupné z DOI:.
9. Suzuki K, Inomata M, Shiraishi S et al. Thymoma with autoimmune hemolytic anemia. Case Rep Oncol. 2014;7(3):764-768. Published 2014 Nov 19. Dostupné z DOI:.
10. Fletcher AL, Calder A, Hince MN et al. The contribution of thymic stromal abnormalities to autoimmune disease. Crit Rev Immunol. 2011; 31(3): 171–187. Dostupné z DOI:.
11. Fábryová V, Cupaníková D, Grmanová L et al. Imunohematológia a transfúzna medicína pre prax. In: Libuša Ceizelová, Adriena Sakalová. Grada: Bratislava 2012: 69–70, ISBN 978-80-8090-002-1.
12. Go RS, Winters JL, Kay NE. How I treat autoimunne hemolytic anemia. Blood 2017; 129(22): 2971–2979. Dostupné z DOI:.
13. Adam Z, Belada D, Bělohlávková P et al. Léčebné postupy v hematologii 2020. Doporučení České hematologické společnosti České lékařské společnosti Jana Evangelisty Purkyně. In Doubek M, Mayer J. Česká hematologická společnost ČLS JEP: 2020:481-485, ISBN 978-80-270-8240-7. Dostupné z WWW:.
14. Zhao J, Bhatnagar V, Ding L et al. A systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected cases. J Thorac Cardiovasc Surg. 2020; 160(1): 306–314.e14. Dostupné z DOI:. Vydáváme knihy
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2021 Issue 4
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