Current view of diagnosis and treatment of latent autoimmune diabetes in adults
Authors:
Jana Urbanová 1; Ludmila Brunerová 1; Jana Malinovská 2; Barbora Pelechová 2; Ludmila Koberová 2; Jan Brož 2
Authors‘ workplace:
Centrum pro výzkum diabetu, metabolismu a výživy, II. interní klinika 3. LF UK a FNKV Praha
1; Interní klinika FN v Motole a 2. LF UK, Praha
2
Published in:
Vnitř Lék 2021; 67(2): 97-102
Category:
Overview
Latent Autoimmune Diabetes in Adults (LADA) is an autoimmune disease arising at adulthood. LADA is characterized by a less intensive autoimmune process, slower progression and a mild metabolic decompensation at onset compared with young-onset type 1 diabetes mellitus. The onset of LADA is usually in non-obese patients over 30, without prominent features of metabolic syndrome and insulin resistance. Nevertheless it may be falsely classified as type 2 diabetes, especially, when diagnosed in older age and for the possibility of non-insulin treatment for at least 6 months after diagnosis. LADA is treated early with insulin and combined with metformin in patients with a higher level of insulin resistance. Clinical studies suggested also effectivity of other oral antidiabetics enabling preservation of residual β-cell function, such as particularly incretines.
Keywords:
diabetes mellitus – diagnosis – GADA – LADA – therapy
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
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