Age‑related myocardial remodeling: myth or reality?

Czech version

Authors: Radek Pudil
Authors‘ workplace: 1. interní kardiongiologická klinika LF UK a FN Hradec Králové
Published in: Vnitř Lék 2020; 66(8): 507-511
Category:

Overview

Age-related myocardial remodeling is a long-term process that involves a wide range of pathogenetic mechanisms. The result is structural and functional changes of the myocardium, which lead to a change in the functional myocardium itself (changes in the geometry of the heart compartments, myocardial contractility, myocardial reserves). These changes can lead to the development of heart failure, reduce the quality of life and thus increase the morbidity and mortality of patients. It is a process that can be negatively affected by risk factors for cardiovascular disease, many comorbidities, on the contrary, this process can be significantly positively influenced by lifestyle changes, early detection of risk factors and consistent treatment of all comorbidities.

Keywords:

aging – myocardial remodeling – Senescence – heart failure

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