Kardiovaskulární riziko nesteroidních antirevmatik
Authors:
Štefan Alušík 1; Zoltán Paluch 2
Authors‘ workplace:
Department of Internal Medicine, Institute for Postgraduate Medical Education, Prague
1; Department of Pharmacology, Charles University Medical School 2, Prague
2
Published in:
Vnitř Lék 2018; 64(3): 266-271
Category:
Reviews
Overview
Nesteroidní protizánětlivé léky (non-steroidal anti-inflammatory drugs – NSAIDs) patří k nejčastěji používaným léčivům. Výsledky rozsáhlých metaanalýz klinických studií publikovaných v posledních letech ukázaly, že kardiovaskulární riziko nesteroidních antirevmatik je závažnější, než se doposud myslelo a není vázáno výlučně na koxiby. Zvyšují ho ale i tzv. tradiční nesteroidní antirevmatika. Z dosavadních poznatků vyplývá, že z pohledu kardiovaskulárního rizika k nejbezpečnějším přípravkům patří naproxen a ibuprofen v malých dávkách. Pozice naproxenu jako nejbezpečnějšího nesteroidního antirevmatika je některými novějšími nálezy poněkud zpochybňována. Autoři přispívají do diskuse o některých výsledcích metaanalýz klinických studií i závěrech regulátorů.
Klíčová slova:
diklofenak – ibuprofen – kardiovaskulární riziko – koxiby –naproxen – nesteroidní antirevmatika
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
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