Differential diagnostics of hypereosinophilia

Czech version

Authors: Michael Doubek ¹; Yvona Brychtová ¹; Jarmila Kissová ²; Miroslav Tomíška ¹; Zdeněk Adam ¹
Authors‘ workplace: Interní hematologická a onkologická klinika LF MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jiří Mayer, CSc. ¹; Oddělení klinické hematologie FN Brno, přednosta prof. MUDr. Miroslav Penka, CSc. ²
Published in: Vnitř Lék 2014; 60(Suppl 2): 21-27
Category: 70th Birthday - prof. MUDr. Jiří Vorlíček, CSc.

Overview

Hypereosinophilia is characterized by chronic increase of peripheral blood eosinophiles with common damage to various organs due to eosinophilic infiltration and release of mediators. Hypereosinophilia should be both reactive and clonal, and accompanies group of heterogeneous disorders (infectious, pulmonary, immunologic, malignant). Based on recent advances in molecular and genetic diagnostic techniques and increasing experience with differences in clinical features and prognosis, some subtypes of clonal hypereosinophilic syndromes have been defined, such as myeloproliferative variants, including chronic eosinophilic leukemia, and lymphocytic variants, but other subtypes remain undefined. Differential diagnostics oh hypereosinophilie therefore remains one of very important medical issues.

Key words:
differential diagnostics – hypereosinophilia

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