Pathology of histiocytoses of non-Langerhans cell type

Czech version

Authors: L. Plank ^1,2
Authors‘ workplace: Ústav patologickej anatómie a Konzultačné centrum bioptickej diagnostiky ochorení krvotvorby Jesseniovej lekárskej fakulty UK a UN Martin, Slovenská republika, prednosta prof. MU Dr. Lukáš Plank, CSc. ¹; Martinské bioptické centrum, s. r. o., Martin, Slovenská republika ²
Published in: Vnitř Lék 2010; 56(Supplementum 2): 39-63
Category: Langerhans cell histiocytosis and some other Hematology rare diseases

Overview

The paper offers a review on pathology of histiocytoses of non-Langerhans cell type, especially focused on neoplastic forms of the histiocytic disorders according to the WHO classification of tumours of hematopoietic and lymphoid tissues (2008). The review is based on lineage- specific histogenetical typing of histiocytic and dendritic cells distinguishing histiocytes (makrophages), dendritic cells of myeloid origin and dendritic cells of the stromal type (of mesenchymal origin). The tumours are classified as follows: histiocytic sarcoma, sarcoma of interdigitating, indetermined, dermal (intersticial) and plasmacytoid dendritic cellss and sarcomas (tumours) of follicular dendritic and fibroblastic reticular cells. Within each of the tumor categories, the histogenesis, clinical manifestation and prognosis is discussed and the histomorphology and phenotypic profile of the tumour is shortly described. Besides that also the relations of all these tumours to fibrohistiocytic tumours of the soft tissue category leading to classification conceptual problems are discussed.

Key words:
histiocyte – dendritic cells – non-Langerhans cell histiocytoses – histiocytic sarcoma – dendritic cell sarcomas and tumours – fibrohistiocytic soft tissue tumours

Sources

1. Adam Z, Adamová Z. Histiocytární choroby a mastocytózy. Diagnostické a léčebné postupy u maligních chorob. Praha: Grada Publishing 2004: 547– 551.

2. Adam Z, Pour L, Veselý K et al. Interdigitating dendritic cell sarcoma of the leg. Onkologie 2009; 32: 364– 365.

3. Adam Z, Krejčí M, Pour L. Histiocytární choroby. Vnitř Lék 2009; 55 (Suppl 1): S109– S124.

4. Adam Z, Balšíková K, Pour L et al. Dia-betes insipidus, následovaný po 4 letech dysartrií a lehkou pravostrannou hemiparézou – první klinické příznaky Erdheimovy- Chesterovy nemoci. Popis a zobrazení případu s přehledem informací o této nemoci. Vnitř Lék 2009; 55: 1173– 1188.

5. Adam Z, Balšíková K, Krejčí M et al. Centrální diabetes insipidus u dospělých osob – první příznak histiocytózy z Langerhansových buněk a Erdheimovy- Chesterovy choroby. Popis tří případů a přehled literatury. Vnitř Lék 2010; 56: 138– 148.

6. Adam Z, Zahradová L, Krejčí M et al. Difuzní plošná normolipemická xantomatóza a nekrobiotický xantogranulom, asociované s monoklonální gamapatií – přínos PET- CT pro stanovení rozsahu nemoci a zkušenosti s léčbou. Popis dvou případ a přehled literatury. Vnitř Lék 2010; 56: 1158– 1168.

7. Alexiev BA, Sailey CJ, McClure SA et al. Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. Diagn Pahtol 2007; 2: 7. Available from: www.diagnosticpathology.org/content/2/I/7.

8. Andriko JA, Kaldjian EP, Tsokos M et al. Reticulum cell neoplasms of lymph nodes: a clinicopathologic study of 11 cases with recognition of a new subtype derived from fibroblastic reticular cells. Am J Surg Pathol 1998; 22: 1048– 1058.

9. Arai E, Yamamoto T, Shimada S et al. Primary cutaneous true histiocytic sarcoma: A case with an indolent course. J Clin Exp Hematopathol 2003; 43: 35– 41.

10. Bassarova A, Trøen G, Fosså A et al. Transformation of B- cell lymphoma to histiocytic sarcoma: somatic mutations of PAX- 5 gene with loss of expression can not explain transdifferentiation. J Hematop 2009; 2: 135– 141.

11. Béné MC, Feuillard J, Jacob MC et al. Plasmacytoid dendritic cells: from the plasmacytoid T- cell to type 2 dendritic cells CD4+CD56+ malignancies. Semin Hematol 2003; 40: 257– 266.

12. Brunning RD, McKenna RW. Histiocytic proliferations of the bone marrow. In: Brunning RD, McKenna RW (eds). Tumors of the bone marrow. Atlas of tumor pathology. 3rd ed. Washington: AFIP 1993: 439– 455.

13. Brychtová S, Bezděková M, Brychta T. Fibroblasty – buňky známé či neznámé? Čes Slov Patol 2010; 46: 29– 32.

14. Bubanská E, Plank L, Szépe P et al. Juvenilná myelomonocytová leukémia asociovaná s neurofibromatózou a komplikovaná hemofagocytovým syndrómom. Čes Slov Pediat 2008; 63: 24– 32.

15. Cao M, Eshoa C, Schultz C et al. Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature. Arch Pathol Lab Med 2007; 131: 301– 305.

16. Cossu A, Lissia A, Dedola MF et al. Classic follicular dendritic reticulum cell tumor of the lymph node developing in a patient with a previous inflammatory pseudotumor-like proliferation. Hum Pathol 2005; 36: 207– 211.

17. Cossu A, Deiana A, Lissia A et al. Synchronous interdigitating dendritic cell sarcoma and B- cell small lymphocytic lymphoma in a lymph node. Arch Pathol Lab Med 2006; 130: 544– 547.

18. Cota C, Vale E, Viana I et al. Cutaneous manifestation of blastic plasmacytoid denderitic cell neoplasm – morphologic and phenotypic variability in a series of 33 patients. Am J Surg Pathol 2010; 34: 75– 87.

19. Dalle JH, Leblond P, Decouvelaere A et al. Effect of thalidomide in a child with histiocytic sarcoma following allogeneic bone marrow transplanstation for T- ALL. Leukemia 2003; 17: 2056– 2057.

20. Danihel Ľ, Plank L. Nádory krvi v krvotvorného tkaniva. In: Siman J (ed). Princípy chirurgie. Bratislava: SAP 2007: 742– 756

21. Dehner LP. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol 2003; 27: 579– 593.

22. Dictor M, Warenholt J, György C et al. Clonal evolution to histiocytic sarcoma with the BCR/ ABL rearrangement 14 years after acute lymphoblastic leukemia. Leuk Lymphoma 2009; 50: 1892– 1895.

23. Dion E, Graef C, Haroche J et al. Imaging of thoracoabdominal involvement in Erdheim- Chester disease. AJR Am J Roentgenol 2004; 183: 1253– 1260.

24. Dong Y, Wu B, Sheng Z et al. Cytokeratin-positive interstitial reticulum cell tumors of lymph nodes: a case report and review of literature. Chin Med J 2008; 121: 658– 663.

25. Eble JN, Rosenberg AE, Young RH. Retroperitoneal xanthogranuloma in a patient with Erdheim- Chester disease. Am J Surg Pathol 1994; 18: 843– 848.

26. Elner VM, Mintz R, Demirci H et al. Local corticosteroid treatment of eyelid and orbital xanthogranuloma. Trans Am Ophthalmol Soc 2005; 103: 69– 74.

27. El- Tatawy R, Mansour L, Gawish K et al. Histiocytic sarcoma, histologic and immuno- phenotypic analysis: a case study. Egyptian Dermatol Online Journals 2008. Available from: www.edoj.org.eg.

28. Favara BE, Feller AC, Pauli M et. al. Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/ Reticulum Cell Proliferations, Reclassification Working Group of the Histiocytic Society. Med Pediatr Oncol 1997; 29: 157– 166.

29. Feldman AL, Minniti C, Santi M et al. Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. Lancet Oncol 2004; 5: 248– 250.

30. Feldman AL, Arber DA, Pittaluga S et al. Clonally related follicular lymphoma and histiocytic/ dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood 2008; 111: 5433– 5439.

31. Ferry JA, Harris NL. Atlas of lymphoid hyperplasia and lymphoma. Philadelphia: W.B. Saunders 1997.

32. Filo V, Buchvald J, Rasochová E et al. Perforating lipoidic necrosis: successful treatment with cyclosporin A. J Dermatol Treatment 1998; 9: 41– 43.

33. Gaertner EM, Tsokos M, Derringer GA et al. Interdigitating dendritic cell sarcoma. A report of four cases and review of the literature. Am J Clin Pathol 2001; 115: 589– 597.

34. Gong L, He XL, Li YH et al. Clonal status and clinicopathologic feature of Erdheim- Chester disease. Pathol Res Pract 2009; 205: 601– 607.

35. Gorczyca W, Emmons F. Other tumors. In: Gorczyca W, Emmons F (eds). Atlas of differential diagnosis in neoplastic hematopathology. 2nd ed. London: Informa 2008: 464– 474.

36. Gould VE, Bloom KJ, Franke WW et al. Increased numbers of cytokeratin-positive interstitial reticulum cells (CIRC) in reactive, inflammatory and neoplastic lymphadenopathies: hyperplasia or induced expression? Virchows Arch 1995; 425: 617– 629.

37. Grogg KL, Macon WR, Kurtin PJ et al. A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. Mod Pathol 2005; 18: 260– 266.

38. Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol 2004; 28: 1133– 1144.

39. Histiocyte society. Available from: www.histiocytesociety.org/site/.

40. Chan AC, Chan KW, Chan JK et al. Development of follicular dendritic cell sarcoma in hyaline- vascular Castleman’s disease of the nasopharynx: tracing its evolution by sequential biopsies. Histopathology 2001; 38: 510– 518.

41. Chantranuwat C. Systemic form of juvenile xanthogranuloma: report of a case with liver and bone marrow involvement. Pediatr Dev Pathol 2004; 7: 646– 648.

42. Chen W, Lau SK, Fong D et al. High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/ dendritic cell sarcomas. Am J Surg Pathol 2009; 33: 863– 873.

43. Cheuk W, Cheung FY, Lee KC et al. Cutaneous indeterminate dendritic cell tumor with a protracted relapsing clinical course. Am J Surg Pathol 2009; 33: 1261– 1263.

44. Jaffe ES, Harris NL, Stein H et al. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissue. Lyon: IARC Press 2001.

45. Jaffe R. Disorders of histiocytes. In: Hsi ED (ed). Hematopathology. Philadelphia: Elsevier Inc. 2007: 513– 550.

46. Kačírková P, Campr V. Hematoonkologický atlas krve a kostní dřeně. Praha: Grada Publishing 2007.

47. Kanaan H, Al-Maghrabi J, Linjawi A et al. Interdigitating dendritic cell sarcoma of the duodenum with rapidly fatal course: a case report and review of the literature. Arch Pathol Lab Med 2006; 130: 205–208.

48. Karimi K, Jadidian A, Glavin FL et al. Laryngeal involvement in progressive nodular histiocytosis: a case report. Arch Otolaryngol Head Neck Surg 2010; 136: 513– 516.

49. Katakai T, Hara T, Sugai M et al. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med 2004; 200: 783– 795.

50. Kawachi K, Nakatani Y, Inayama Y et al. Interdigitating dendritic cell sarcoma of the spleen: report of a case with a review of the literature. Am J Surg Pathol 2002; 26: 530– 537.

51. Khan AA, Agarwahl A, Chaddha SK et al. Histiocytic sarcoma of the terminal ileum presenting as a large ulcerating lesion: CT diagnosis. Radiol Case Reports Online 2009; 4: 262– 266.

52. Kim NR, Ko YH, Choe YH et al. Erdheim- Chester disease with extensive marrow necrosis: a case report and literature review. Int J Surg Pathol 2001; 9: 73– 79.

53. Kim WY, Kim H, Jeon YK et al. Follicular dendritic cell sarcoma with immature T- cell proliferation. Hum Pathol 2010; 41: 129– 133.

54. Kolenova A, Plank L, Subova Z et al. Histiocytic sarcoma as a second malignancy following T- ALL. Pediat Blood Cancer 2010. V tisku.

55. Kraus MD, Haley RC, Ruiz R et al. „Juvenile“ xanthogranuloma: an immunophenotypic study with reappraisal of histogenesis. Am J Dermatopathol 2001; 23: 104– 111.

56. Krokowski M, Merz H, Thorns C et al. Sarcoma of follicular dendritic cells with features of sinus lining cells – a new subtype of reticulum cell sarcoma? Virchows Arch 2008; 452: 565– 570.

57. Leenen PJ, Bechan GI, Melis M et al. Heterogeneity in a mouse model of histiocytosis: transformation of Langerin+ dendritic cells, macrophages, and precursors. J Leukoc Biol 2010; 87: 949– 958.

58. Lennert K, Remmele W. Karyometrische Untersuchungen an Lymphknotenzellen des Menschen: I. Mitt. Germinoblasten, Lymphoblasten und Lymphozyten. Acta Haematol 1958; 19: 99– 113.

59. Lennert K, Mohri N, Stein H et al. Malignant Lymphomas other than Hodgkin’s Disease. Berlin, Heidelberg, New York: Springer Verlag 1978.

60. Liang S, Liu YH, Fang K. Juvenile xanthogranuloma with ocular involvement. Pediatr Dermatol 2009; 26: 232– 234.

61. Louis DN, Ohgaki H, Wiestler OD et al. WHO classification of Tumours of the Central nervous System. 4th ed. Lyon: IARC 2007.

62. Martel M, Sarli D, Colecchia M et al. Fibroblastic reticular cell tumor of the spleen: report of a case and review of the entity. Hum Pathol 2003; 34: 954– 957.

63. Miettinen M, Fetsch JF. Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases. Am J Surg Pathol 2006; 30: 521– 528.

64. Minariková E, Plank L, Péč J. Kazuistický prípad pacienta s blastickým NK- bunkovým lymfómom, syn. CD4+/ CD56+ hematodermická neoplázia, syn. včasná plazmocytoidná leukémia/ lymfóm z dendritických buniek. Čes Slov Derm 2008; 83: 204– 208.

65. Oka K, Nakamine H, Maeda K et al. Primary histiocytic sarcoma of the spleen associated with haemophagocytosis. Int J Haematol 2008; 87: 405– 409.

66. Park MI, Song KS, Kang DY. Histiocytic sarcoma of the rectum: a case report. Korean J Pathol 2006; 40: 156– 159.

67. Petrella T, Comeau MR, Maynadié M et al. Agranular CD4+ CD56+ hematodermic neoplasm (blastic NK- cell lymphoma) originates from a population of CD56+ precursor cells related to plasmacytoid monocytes. Am J Surg Pathol 2002; 26: 852– 862.

68. Pileri SA, Grogan TM, Harris NL et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 2002; 41: 1– 29.

69. Plank L, Huťka Z, Beseda A et al. Morbus Ormond a sekundárny nádor. Zborník súhrnov XXXIV. celoštátneho zjazdu československých patológov s medzinárodnou účasťou. Banská Bystrica 1983: 75– 75.

70. Plank L. Atlas biopsie nelymfómových lymfadenopatií. Martin: Osveta 1990.

71. Plank L, Kodet R, Boudová L. Novinky v klasifikácii lymfoidných neoplázií podľa SZO 2008 (4. vydanie). Transf Hematol 2008; 14 (Suppl 1): 69– 71.

72. Plank L, Minariková E, Péč J et al. Klasifikácia kožných malígnych lymfómov podľa novej klasifikácie SZO (2008). Onkológia (Bratislava) 2009; 4: 160– 163.

73. Podberezin M, Angeles R, Guzman G et al. Primary pancreatic sinus histiocytosis with massive lymphadenopathy (Rosai- Dorfman disease): an unusual extranodal manifestation clinically simulating malignancy. Arch Pathol Lab Med 2010; 134: 276– 278.

74. Protopopadakis C, Antoniou KM, Nicholson AG et al. Erdheim- Chester disease: pulmonary presentation in a case with advanced systemic involvement. Respiration 2009; 77: 337– 340.

75. Rezk SA, Spagnolo DV, Brynes RK et al. Indeterminate cell tumor: a rare dendritic neoplasm. Am J Surg Pathol 2008; 32: 1868– 1873.

76. Rosenberg AS, Morgen MB. Cutaneous indeterminate cell histiocytosis: a new spindle cell variant resembling dendritic cell sarcoma. J Cutan Pathol 2001; 28: 531– 537.

77. Serratrice J, Granel B, De Roux B et al. „Coated aorta“: a new sign of Erdheim- Chester disease. J Rheumatol 2000; 27: 1550– 1553.

78. Shinoda H, Yoshida A, Teruya- Feldstein J. Malignant histiocytoses/ disseminated histiocytic sarcoma with hemophagocytic syndrome in a patient with mediastinal germ cell tumor. Appl Immunohistochem Mol Morphol 2009; 17: 338– 344.

79. Shoo BA, Shinkai K, McCalmont TH et al. Xanthogranulomas associated with hematological malignancy in adulthood. J Am Acad Dermatol 2008; 59: 488– 493.

80. Schuerfeld K, Lazzi S, De Santi MM et al. Cytokeratin-positive interstitial cell neoplasm: a case report and classification issues. Histopathology 2003; 43: 491– 494.

81. Stašková K, Ježíková A, Michalicová A et al. Morbus Ormond. Rheumatologia 2009; 23: 99– 99.

82. Swerdlow SH, Campo E, Harris NL et al. WHO classification of tumours of heamatopoietic and lymphoid tissues. 4th ed. Lyon: IARC 2008.

83. Ugurlu S, Bartley GB, Gibson LE. Necrobiotic xanthogranuloma: long term outcome of ocular and systemic involvement. Am J Ophthalmol 2000; 129: 651– 657.

84. Ueda T, Kawano H. Xanthogranulomatous transformation of metastatic testicular tumor. Urology 1983; 22: 646– 648.

85. Urosevic M, Conrad C, Kamarashev J et al. CD4+ CD56+ hematodermic neoplasms bear a plasmacytoid dendritic cell phenotype. Hum Pathol 2005; 36: 1020– 1024.

86. Vencio EF, Jenkins RB, Schiller JH et al. Clonal cytogenetic abnormalities in Erdheim- Chester disease. Am J Surg Pathol 2007; 31: 319– 321.

87. Venkataraman G, McClain KL, Pittaluga S et al. Development of disseminated histiocytic sarcoma in a patient with autoimmune lymphoproliferative syndrome and associated Rosai- Dorfman disease. Am J Surg Pathol 2010; 34: 589– 594.

88. Vermi W, Facchetti F, Rosati S et al. Nodal and extranodal tumor- forming accumulation of plasmacytoid monocytes/ interferon producing cells associated with myeloid disorders. Am J Surg Pathol 2004; 28: 585– 595.

89. Veyssier- Belot C, Cacoub P, Caparros- Lefebvre D et al. Erdheim- Chester disease: clinical and radiologic characteristics of 59 cases. Medicine (Baltimore) 1996; 75: 157– 169.

90. Vos JA, Abbondanzo SL, Barekman CL et al. Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Mod Pathol 2005; 18: 693– 704.

91. Cheuk W, Chan JK, Shek TW et al. Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low- grade malignant intra- abdominal neoplasm with consistent Epstein-Barr virus association. Am J Surg Pathol 2001; 25: 721– 731.

92. Wang E, Hutchinson CB, Huang Q et al. Histiocytic sarcoma arising in indolent small B- cell lymphoma: report of two cases with molecular/ genetic evidence suggestive of a „transdifferentiation“ during the clonal evolution. Leuk Lymphoma 2010; 51: 802– 812.

93. Weiss SW, Goldblum JR. Chapter 12– 14: Benign fibrohistiocytic tumors. Fibrohistiocytic tumors of intermediate malignancy. Malignanf fibrous histiocytoma. In: Enzinger and Weiss’s Soft tissue tumors. 5th ed. Philadelphia: Mosby Elesevier 2008: 331– 428.

94. Willemze R, Jaffe ES, Burg G et al. WHO- EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768– 3785.

95. Zelger B, Eisendle K, Mensing C et al. Detection of spirochetal micro-organisms by focus- floating microscopy in necrobiotic xanthogranuloma. J Am Acad Dermatol 2007; 57 1026– 1030.