Complications of obesity – pathogenesis

Czech version

Authors: B. Krahulec
Authors‘ workplace: II. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, prednosta prof. MU Dr. Andrej Dukát, CSc., FESC
Published in: Vnitř Lék 2010; 56(10): 1050-1052
Category: Obesity 2010

Overview

Author discuss possible patogenetic mechanisms of obesity complications. He separates metabolic complications, especially risk factors of atherosclerosis collected in syndrome of insulin resistance. Here can be added also hyperuricaemia and nonalcoholic fatty liver disease. Mechanical complications of obesity are first of all breath disorders, gastrooesophageal reflux disease and ostaoarthritis.

Key words:
complications of obesity – pathogenesis – metabolic complication – mechanical complication

Sources

1. Müllerová D et al. Obezita – prevence a léčba. Praha: Mladá fronta 2009.

2. Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008; 93 (11 Suppl 1): S64– S73.

3. Malnick SD, Knobler H. The medical complications of obesity. QJM 2006; 99: 565– 579.

4. Ukropcová B, Ukropec J, Klimeš I at al. Endokriná funkcia tukového tkaniva. Via Practica 2008; 5: 115– 121.

5. Galajda P. Metabolický syndróm, kardiovaskulárne a metabolické riziká. Via Practica 2007; 4: 5– 9.

6. Krahulec B. Inzulínová rezistencia a kardiovaskulárne následky – významná úloha endotelovej dysfunkcie. Diabetes Obezita 2003; 3: 9– 15.

7. Wilson PW, D’Agostino RB, Sullivan L et al. Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 2002; 162: 1867– 1872.

8. Haffner SM, Lehto S, Rönnemaa T. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339: 229– 234.

9. Anděl M, Polák J, Kraml P et al. Chronický mírný zánět spojuje obezitu, metabolický syndrom, aterosklerózu a diabetes. Vnitř Lék 2009; 55: 659– 665.

10. Song YM, Sung J, Davey Smith G et al. Body mass index and ischemic and hemorrhagic stroke: a prospective study in Korean men. Stroke 2004; 35: 831– 836.

11. Curtis JP, Selter JG, Wang Y et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005; 165: 55– 61.

12. Benjamin EJ, Levy D, Vaziri SM et al. Independent risk factors for atrial fibrillation in a population‑based cohort: the Framingham Heart Study. JAMA 1994; 271: 840– 844.

13. Brůha R, Dvořák K. Nealkoholická steatóza a steatohepatitída. Interní Med 2007; 5: 210– 212.

14. Suzuki A, Lindor K, St Saver J et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol 2005; 43: 1060– 1066.

15. Ishizaka N, Ishizaka Y, Toda E et al. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol 2005; 25: 1038– 1044.

16. Tsunoda S, Kamide K, Minami J et al. Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low- energy diet and an insulin‑sensitizing agent. Am J Hypertens 2002; 15: 697– 701.

17. Bickelmann AG, Burwell CS, Robin ED et al. Extreme obesity associated with alveolar hypoventilation: a Pickwickian syndrome. Am J Med 1956; 21: 811– 818.

18. Teichtahl H. The obesity-hypoventilation syndrome revisited. Chest 2001; 120: 336– 339.

19. Matějovič M. Obézní pacient v intenzivní péči. In: Müllerová D et al (eds). Obezita – prevence a léčba. Praha: Mladá fronta, 2009: 246– 250.

20. Hampel H, Abraham NS, El‑ Serag HB. Meta‑analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005; 143: 199– 211.

21. Pottie P, Presie N, Terlain B et al. Obesity and osteoarthritis: more complex than predicted! Ann Rheum Dis 2006; 65: 1403– 1405.