Insulin Sensitizing Drugs

Czech version

Authors: A. Šmahelová
Authors‘ workplace: Diabetologické centrum, vedoucí doc. MUDr. Alena Šmahelová, Ph. D., Kliniky gerontologické a metabolické Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Luboš Sobotka, CSc.
Published in: Vnitř Lék 2009; 55(4): 425-428
Category:

Overview

Currently, insulin sensitizing drugs in the form of metformin as the basic drug are part of the treatment of practically any type II diabetic patient. At the beginning of the therapy, metformin is used; later, insulin sensitizers (PPAR‑γ stimulators) such as rosiglitazone and pioglitazone are often applied. Nowadays, extensive research into new pharmaceuticals is being conducted in the group of insulin sensitizers. So-called double sensitizers, panPPAR sensitizers or PPAR‑γ sensitizers, are being developed. The most promising group is of the PPAR‑γ selective modulators.

Key words:
metformin – rosiglitazone – pioglitazone – PPAR sensitizers – selective PPAR modulators – panPPAR sensitizers

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