Mucosal immunity with emphasise on urinary tract immunity and diabetes

Czech version

Authors: J. Krejsek; M. Kudlová; M. Koláčková; J. Novosad
Authors‘ workplace: Ústav klinické imunologie a alergologie Lékařské fakulty UK a FN Hradec Králové, přednosta prof. RNDr. Jan Krejsek, CSc.
Published in: Vnitř Lék 2008; 54(5): 478-481
Category:

Předneseno na 9. celostátním diabetologickém sympoziu „Diabetes a urogenitální systém“ ve dnech 1.-2. června 2007 v Novém Adalbertinu v Hradci Králové

Overview

Protective immune response in urinary tract is frequently impaired in patients with diabetes. Immunity in this mucosal compartment displays unique characteristics; e.g. absence of physiological microflora and lack of mucus. Pathogens are identified by the PRR receptors expressed on both epithelial and immune cells. Inflammatory response characterised by the acumulation of granulocytes is followed. Both protective and harm characteristics of inflammatory response are inseparable linked and delineated by gene polymorphisms in PRR receptors.

Key words:
diabetes mellitus - mucosal immunity - urinary tract - infection

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