Human leukocyte differentiation antigens and CD classification
Authors:
K. Koubek
Authors‘ workplace:
Ústav hematologie a krevní transfuze Praha, ředitel prof. MUDr. Pavel Klener, DrSc.
Published in:
Vnitř Lék 2008; 54(4): 402-409
Category:
Review
Overview
The autor summarizes the information about human leukocyte antigens. Expression of membrane markers is included in accordance with CD (Cluster of Differentiation) classification. The CD molecules are used ubiquitously in human medical research, immunodiagnosis and treatment and also CD profiles are intended to be used by biologists, pathologists and clinicians generally. Profiles nearly 400 known leukocyte cell surface molecules are summarized in CD system (CD1–CD350). Most CD molecules are integral membrane proteins that have one or more pass through the plasma cell membranes. Knowing which regions of a protein are intracellular or extracellular is important in the selection of peptides for immunization, for the expression of domains of the protein, and to understand the interaction of the protein with other proteins. CD markers are great targets for diagnostic and research of different types of diseases as a potential treatment for a variety of tumors.
Keywords:
leukocyte and erytrocyte antigens – HCMD system – workshops
Sources
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Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2008 Issue 4
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