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Reliability of clinical indicators of neonatal sepsis


Authors: P. Rabasová;  L. Sikorová
Authors‘ workplace: Vedoucí: doc. PhDr. Darja Jarošová, Ph. D. ;  Ústav ošetřovatelství a porodní asistence ;  Lékařská fakulta ;  Děkan: doc. MUDr. Pavel Zonča, Ph. D., FRCS ;  Ostravská univerzita v Ostravě
Published in: Prakt. Lék. 2015; 95(3): 131-140
Category: Of different specialties

Overview

Aim:
To find out which determining clinical signs occur most frequently at neonatal sepsis.

Methods:
searching for valid indicators of sepsis in newborns using the method of evidence-based practice. Specialized licensed databases and freely accessible databases were used for obtaining relevant sources – Academic Search Complete, Medline, CINAHL, Web of Science, ScienceDirect, Scopus, Wiley, Google, Google Scholar.

Results:
Analysis of the results did not show the unequivocal reliability of individual indicators of sepsis. Most of the results agreed with the clinical significance of following clinical indicators: respiratory disorders (respiratory distress, increased rate of breathing over 60 breaths per minute, chest retraction, grunting, apnea), neurological disorders (convulsions, lethargy, irritability, hypotonia), impaired thermoregulation (hypothermia / hyperthermia), gastrointestinal disorders (problems with feeding, vomiting, abdominal distension), peripheral circulatory disorders (cyanosis, prolonged capillary refill time), central circulatory disorders (tachycardia, hypotension), skin changes (jaundice, petechiae, pustules, etc.). Other symptoms are classified as complementary.

Conclusion:
15 analyzed studies show some evidence confirming the reliability of the recommended evaluated symptoms that indicate sepsis in newborns. The best predictive value, according to all authors, has an assessment of a combination of all clinical and laboratory markers of sepsis.

Keywords:
sepsis – newborn – symptoms – diagnostics


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