Fecal microbiota transplantation and novel therapies for Clostridium difficile infection
Authors:
J. Vejmelka; P. Kohout; J. Koten; Z. Beneš
Authors‘ workplace:
Interní oddělení
; Primář: doc. MUDr. Zdeněk Beneš, CSc.
; Thomayerova nemocnice, Praha
Published in:
Prakt. Lék. 2014; 94(4): 195-200
Category:
Of different specialties
Overview
Clostridium difficile infection (CDI) represents a serious chronic disease with typical chronic and recurrent course. The number of patiens with recurrent CDI is still growing and currently used therapeutic approaches are not always effective. We successfully cured two patients by fecal microbiota transplantation and discuss the role of fecal microbiota transplantation in the CDI treatment algorithm. Novel CDI treatments discovery, necessity of strictly rational antibiotic use and probiotic use in prevention of CDI and its recurrencies are also mentioned.
Keywords:
Clostridium difficile infection (CDI) – fecal microbiota transplantation – new approaches to treatment – rational antibiotic use
Sources
1. Polák P, Freibergerová M, Juránková J, Kocourková H, Mikešová L, Svačinka R, Husa P. První zkušenosti s fekální bakterioterapií v léčbě relabující pseudomembranózní kolitidy způsobené Clostridium difficile. Klin Mikrobiol Infekc Lek 2011; 17(6): 214–217.
2. Beneš J, Husa P, Nyč O. Doporučený postup diagnostiky a léčby kolitidy vyvolané Clostridium difficile [on-line]. Dostupný na: www.infekce.cz/Standardy/dopCDI12.rtf [cit. 6-1-2013].
3. Zhang F, Luo W, Shi Y, et. al. Should we standardize the 1700-years-old fecal microbiota transplantation? Am J Gastroenterol 2012; 107(11): 1755.
4. Borody TJ, Warren EF, Leis SM, et al. Bacteriotherapy using fecal flora: toying with human motions. J Clin Gastroenterol 2004; 38: 475–483.
5. Eiseman B, Silen W, Bascom GS, et al. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery 1958; 44: 854–859.
6. Schwan A, Sjolin S, Trottestam U, et al. Relapsing Clostridium difficile enterocolitis cured by rectal infusion of homologous faeces. Lancet 1983; 2: 845.
7. Brand LJ, Aroniadis OC. An overview of fecal microbiota transplantation: techniques, indications, and outcomes. Gastrointest Endosc 2013; 78(2): 240–249.
8. Kassam Z, Lee CH, Yuan Y, Hunt RH. Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol 2013; 108(4): 500–508.
9. Chen X, D'Souza R, Hong ST. The role of gut microbiota in the gut-brain axis: current challenges and perspectives. Protein Cell 2013; 4(6): 403–414.
10. Brandt LJ, Aroniadis OC. Fecal microbiota transplantation: past, present and future. Curr Opin Gastroenterol 2013; 29: 79–84.
11. Brandt LJ, Aroniadis OC, Mellow M, et al. Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection. Am J Gastroenterol 2012; 107(7): 1079–1087.
12. Persky S, Brandt LJ. Treatment of recurrent Clostridium difficile-associated diarrhoea by administration of donated stool directly through a colonoscope. Am J Gastroenterol 2000; 95: 3283–3285.
13. Hamilton MJ, Weingarden AR, Sadowsky MJ, et al. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am J Gastroenterol 2012; 107: 761–767.
14. Gough E, Shaikh H, Manges AR. Systemic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 2011; 53: 994–1002.
15. Brown KA, Khanafer N, Daneman N, Fisman DN. Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection. Antimicrob Agents Chemother 2013; 57(5): 2326–2332.
16. Deshpande A, Pant C, Pasupuleti V, et al. Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analysis. Clin Gastroenterol Hepatol 2012; 10(3): 225–233.
17. Lowe DO, Mamdani MM, Kopp A, et al. Proton Pump Inhibitors and Hospitalisation for Clostridium difficile-Associated Disease: A Population-Based Study. Clin Infect Dis 2006; 43: 1272–1276.
18. Goldenberg JZ, Ma SS, Saxton JD, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2013; 5: CD006095.
19. McFarland L. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006; 101: 812–822.
20. Cornely OA, Crook DW, Esposito R, et al. Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: A double-blind, non-inferiority, randomised controlled trial. Lancet Infect Dis 2012; 12(4): 281–289.
21. Louie TJ, Peppe J, Watt CK, et al. Tolevamer, a novel nonantibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile-associated diarrhea. Clin Infect Dis 2006; 43: 411–420.
22. Nyč O. Přístup k léčbě střevních infekcí způsobených bakterií Clostridium difficile. Klin Mikrobiol Infekc Lek 2010; 16(3): 93–96.
23. Beneš J, Sýkorová B. Kolitida vyvolaná Clostridium difficile. Zpráva z kongresu ICAAC 2006. Klin Mikrobiol Inf Lék 2006; 12: 247–251.
24. Bergmann D, Koten J, Beneš Z, a kol. Pseudomembranózní kolitida. Vnitř. Lék. 2007; 53(10): 645–652.
25. Zela O, Vítek P. Infekce Clostridium difficile – stav v roce 2012. Med. praxi 2012; 9(10): 391–394.
26. Petr J. Střevní mikrobiom v systémovém pojetí. Medical Tribune 1/2012 [on-line]. Dostupné z: http://www.tribune.cz/clanek/25566-strevni-mikrobiom-v-systemovem-pojeti [cit. 6-1-2014].
27. van Nood, E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013; 368(5): 407–415.
28. Petrof EO, Gloor GB, Vanner SJ, et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: „RePOOPulating“ the gut. Microbiome 2013, 1: 3. Dostupné z: http://www.microbiomejournal.com/content/1/1/3 [cit. 6-1-2014].
29. Heineman J, Bubenik S, McClave S, Martindale R. Fighting fire with fire: is it time to use probiotics to manage pathogenic bacterial diseases? Curr Gastroenterol Rep 2012; 14(4): 343–348.
30. Paterson D, Iredell J, Whitby M. Putting back the bugs: bacterial treatment relieves chronic diarrhoea. Med J Aust 2012; 160 (4): 232–233.
31. Joshi NM, Macken L, Rampton D. Inpatient diarrhoea and Clostridium difficile infection. Clin Med 2012; 12(6): 583–588.
32. Didelot X, Eyre D, Cule M, et al. Microevolutionary analysis of Clostridium difficile genomes to investigate transmission. Genome Biol 2012; 13(12): R118.
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General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2014 Issue 4
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