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Omeprazol in the Treatment of Gastropathies Caused by Non-steroid Antirheumatic Drugs. Evaluation of Clinical Effectiveness and Tolerance of the Preparation


Authors: V. Jirásek 1;  D. Pulgertová 2;  J. Petrtýl 3;  M. Samek 4;  O. Shonová 5;  P. Petr 5;  J. Bureš 6;  M. Kunovská 7;  M. Molčík 8;  P. Procházka 9;  Z. Dostalík 10;  J. Doseděl 11;  J. Špičák 12;  K. Lukáš 13;  M. Kment 14*
Authors‘ workplace: I. interní klinika VFN, Praha 2ZÚNZ, Příbram 3I. interní klinika VFN, Praha 4GE oddělení, Most 5GE oddělení nemocnice, České Budějovice 6II. interní klinika FN, Hradec Králové 7III. interní GE klinika FN, Brno 8Sanatorium ELWA, Karlovy Vary 9II. interní k 1
Published in: Prakt. Lék. 2001; (3): 146-149
Category:

Overview

Objective:
Evaluation of the effectiveness and tolerance of the preparation Helicid (Omeprazol Léèiva Co.) in indications of gastropathies caused by non-steroid antirheumatic drugs.Patients and methods: In a group of 113 patients with endoscopically verified gastropathy caused by non-steroid antirheumatics omeprazol was administered - 20 mg/day - for a period of four weeks while antirheumatics were discontinued. The clinical tests were made on a multicentre basis as an open trial respecting all ethical aspects. The tests were monitored independently.Results: From the group of 113 patients 107 could be evaluated. Treatment was successful in 101 patients (94.3%). Complete healing of lesions was recorded in 91 patients (85%), in 10 patients healing was incomplete (9.3%). In 6 patients (5.6%) treatment failed.Undesirable side-effects, in the great majority not serious, were recorded in 17 patients, i.e. 15.3% of the group. In the majority of patients (>80%) the relationship of undesirable effects and treatment was controversial.Conclusion: Helicid proved in gastropathies caused by non-steroid antirheumatics an effective and well tolerated drug with few minor undesirable side-effects.

Key words:
gastropathy - non-steroid antirheumatics - omeprazol - Helicid.

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