How to choose the right IBD patients for vedolizumab treatment

Czech version

Authors: Tkáčik M.
Authors‘ workplace: Gastroenterologická ambulancia NsP Brezno
Published in: Gastroent Hepatol 2020; 74(1): 44-49
Category: IBD: Review Article
doi: https://doi.org/10.14735/amgh202044

Overview

Currently, there are several types of treatment for inflammatory bowel disease, but it is often difficult to decide on the best treatment. The arrival of new biologics helps us to optimize treatment and improve significantly the course of the disease. Vedolizumab is a monoclonal antibody against integrin α4β7. It is gut selective and inhibits vascular adhesion of leucocytes and their migration to the mucosa of the gut, as well as their interactions with mucosal addresins of the gut wall. It is approved for the treatment of moderate to severe form of ulcerative colitis (UC) and Crohn’s disease. Recent studies confirm higher effectivityhave confirmed it to be more effective and safer than adalimumab (VARSITY clinical trial) in both bionaive and anti-tumor necrosis factor exposed (EVOLVE) patients, with higher clinical and endoscopic remission in patients with UC.

Conflict of Interest: The author declares that the article/ manuscript complies with ethical standards, patient anonymity has been respected, and he states that he has no fi nancial, advisory or other commercial interests in relation to the subject matter.

Publication Ethics: This article/ manuscript has not been published or is currently being submitted for another review. The author agrees to publish his name and e-mail in the published article/ manuscript.

Dedication: The article/ manuscript is not supported by a grant nor has it been created with the support of any company.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for bio medical papers.

Keywords:

vedolizumab – anti-TNF – clinical remission – mucosa healing

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