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Does golimumab extend the spectrum of anti-TNFα inhibitors for inflammatory bowel diseases?


Authors: M. Lukáš
Authors‘ workplace: Klinické a výzkumné centrum pro střevní záněty, ISCARE a 1. LF UK v Praze a Ústav klinické biochemie a laboratorní diagnostiky, 1. LF UK v Praze
Published in: Gastroent Hepatol 2012; 66(6): 465-469
Category: IBD: Review Article

Overview

Golimumab is a new drug which belongs to class of anti-TNFα inhibitors. This drug was prepared due to unique synthesis from hybridoma cells lines which were derived from transgenic mouse. The specific golimumab synthesis granted its human origin and some favourable pharmacological properties. In PURSUIT study has been shown that golimumab is very effective the­rapy and induces and maintains a clinical response, clinical remission, mucosal healing and improves the quality of life in patients with moderately to severely active ulcerative colitis. The position of golimumab in clinical practice in patients with ulcera­tive colitis has to be proved in the next clinical studies.

Key words:
biological therapy – ulcerative colitis – inflammatory bowel diseases

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
22. 11. 2012

Accepted:
10. 12. 2012


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Labels
Paediatric gastroenterology Gastroenterology and hepatology Surgery

Article was published in

Gastroenterology and Hepatology

Issue 6

2012 Issue 6

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