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The efficacy of maintenance therapy in ulcerative colitis is influenced by the pharmacokinetics of ­mesalazine and by adherence to medicamentous therapy

Commentary to the PODIUM study


Authors: M. Lukáš
Authors‘ workplace: Klinické a výzkumné centrum pro střevní zánět ISCARE a 1. LF UK v Praze Ústav klinické biochemie a laboratorní diagnostiky 1. LF UK v Praze
Published in: Gastroent Hepatol 2010; 64(5): 26-29
Category: IBD

Overview

In the last year the results of the PODIUM trial were published. The authors investigated the efficacy and safety of once and twice daily administration of prolonged-release mesalazine granules (2 g daily) in the maintenance of remission in patients with quiescent ulcerative colitis. It has been shown that once daily oral mesalazine had better therapeutic results compared with patients given oral mesalazine of 1 g twice daily. The commentary discusses the possibilities explaining the positive effect of a single dose administration of the drug. The most important seems to be the positive impact on mesalazine pharmacokinetics and the significantly better adherence of patients to medicamentous therapy.

Key words:
inflammatory bowel disease – ulcerative colitis – maintenance therapy – mesalazine


Sources

1. Dignass AU, Bokemeyer B, Adamek H et al. Mesalamine once daily is more effective than twice daily in patients with quiescent ulcerative colitis. Clin Gastroenterol Hepatol 2009; 7(7): 762–769.

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3. Lukáš M. Idiopatické střevní záněty a kolorektálním karcinom. Nové souvislosti a další perspektivy. Čes a slov gastroenterol hepatol 2006; 6(3):113–118.

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5. Kruis W, Kiudelis G, Racz I et al. Once-daily versus free-times-daily mesalazine granules i nactive ulcerative colitis: a double-blind, double-dummy, randomised, non-inferiority trial. Gut 2009; 58(2): 233–240.

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Labels
Paediatric gastroenterology Gastroenterology and hepatology Surgery
Topics Journals
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