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Sodium-glucose cotransporter 2 inhibitors in patients with chronic kidney disease without and after kidney transplantation


Authors: Patrícia Kleinová 1,2;  Tímea Blichová 1,2;  Matej Vnučák 1,2;  Karol Graňák 1,2;  Monika Beliančinová 1,2;  Ivana Dedinská 1,2
Authors‘ workplace: Transplantačno-nefrologické oddelenie UNM, Martin 1;  I. interná klinika JLF UK a UNM, Martin 2
Published in: Forum Diab 2024; 13(2): 69-72
Category: Review Article

Overview

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent the first-line treatment for diabetic kidney disease, and have also become part of the treatment algorithm for chronic kidney disease. Gliflozin have significant cardio-renoprotective effects with reduction of albuminuria and stabilization of glomerular filtration rate in patients with chronic kidney disease. Secondary effects (weight reduction, stimulation of erythropoiesis, inhibition of pro-inflammatory parameters) make SGLT2i broad-spectrum agents with the possibility of expanding prescribing restrictions. However, the benefit and safety of use in patients after kidney transplantation remains a question.

Keywords:

kidney transplantation – chronic kidney disease (CKD) – sodium-glucose cotransporter 2 inhibitors (SGLT2i)


Sources

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