Presence and near future of pharmacological treatment of obesity/diabesity

Czech version

Authors: Ubomíra Fábryová ^1,2,3
Authors‘ workplace: MetabolKLINIK s. r. o., Ambulancia pre diabetológiu, poruchy látkovej premeny a výživy, MED PED centrum, Bratislava ¹; Biomedicínske centrum Slovenskej Akadémie Vied, Bratislava ²; Vysoká škola zdravotníctva a sociálnej práce sv. Alžbety, Inštitút prevencie a intervencie, Bratislava ³
Published in: Forum Diab 2022; 11(3): 135-142
Category: Review Article

Overview

Obesity/diabesity is considered worldwide as a global epidemic/pandemic with extensive health and socio-economic consequences, therefore it requires a comprehensive preventive, diagnostic, therapeutic and especially long-term controlled procedure focused on a specific individual, but also requires a societal preventive approach. A very small percentage of patients with obesity/diabesity receive real assistance in the management of obesity and even more important in the management of already reduced weight (dietary and regimen measures, cognitive-behavioral therapy, pharmacotherapy with anti-obesity drugs, bariatric-metabolic surgery, combination of bariatric-metabolic surgery with anti-obesity drugs). Pharmacotherapy with anti-obesity drugs is an important part of the comprehensive management of an obese individual. The ideal anti-obesity drug is one that effectively achieves weight reduction, maintains reduced weight, provides long-term safety and reduces chronic obesity-related diseases. In addition to currently available antiobesity drugs (orlistat, naltrexone SR / bupropion SR), GLP-1 (glucagon-like peptide-1) receptor agonists – currently liraglutide 3.0 mg – are becoming an important part of the management of individuals living with obesity. Treatment must be timely, vigorous and long-term. New hope for even better management of obesity shines with the arrival of other new molecules in clinical practice (semaglutide, oral semaglutide, but also a combination of GLP-1 receptor agonists with amylin, or a combination of two incretins (twin-cretins).

Keywords:

semaglutide – GLP-1 receptor agonists – amylin – liraglutide 3.0 mg – naltrexon SR/bupropion SR – orlistat – pharmacotherapy of obesity/diabesity – tirzepatide – twin-cretins

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Article was published in

Forum Diabetologicum

2022 Issue 3