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proLékaře.cz / Journals / Forum Diabetologicum / 2021 - Supplementum 1

Antidiabetic treatment in prevention of atherosclerosis: last decade

Czech version

Authors: Emil Martinka 1,2
Authors‘ workplace: Národný endokrinologický a diabetologický ústav, n. o., Ľubochňa 1;  Fakulta zdravotníckych vied Piešťany, Univerzita Sv. Cyrila a Metoda, Trnava 2
Published in: Forum Diab 2021; 10(Supplementum 1): 16-27
Category:

Overview

In the last five years, the results of several studies aimed at testing the cardiovascular (CV) safety (so-called “CVOT” studies) of newer antidiabetic drug users have been published, which have attracted special attention and become one of the most important in diabetology. Indeed, they have shown that drugs from the group of SGLT-2 cotransport inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1-RA) are not only cardiovascular safe, but their addition to treatment is associated with a significant reduction in cardiovascular and renal morbidity and mortality even with previously complexive cardioprotective treatment. In the review article, we analyze the results of the most important randomized controlled trials, as well as a study from real practice, as well as the implementation of these findings into therapeutic recommendations.

Keywords:

antidiabetic treatment – Atherosclerosis – cardiovascular diseases – dipeptidyl peptidase 4 inhibitors – GLP1 receptor agonists – SGLT-2 cotransport inhibitors

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Labels
Diabetology Endocrinology Internal medicine
Súčasné možnosti prevencie aterosklerózy pri diabete
Antidiabetic treatment in prevention of atherosclerosis: first half-century
Hypolipidemic treatment in the prevention of atherosclerosis in diabetic patients
Antihypertensive treatment in the prevention of atherosclerosis in diabetic patients
Antiplatelet therapy for prevention of atherosclerosis in patients with diabetes
Effect of antidiabetic treatment on incidence of stroke in patients with type 2. diabetes
Limitation and possible additive value of real world evidence in comparison with randomized clinical trials
Facts to remember: What is based on the evidence in atherosclerosis prevention in type 2 diabetes?
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