Detection of Some new Antidepressants by thin Layer Chromatography

Overview

Series of new antidepressants appeared in the treatment of central nervous system disorders inthe last years. Into this group belong: 1. antidepressants of the 3rd generation which selectivelyinhibit serotonine reuptake; 2. thymoleptics - a group of compounds which have no anticholinergiceffects and act as noradrenaline reuptake inhibitors or noradrenaline and serotonine reuptakeinhibitors; 3. antipsychotics from the group of selective serotonine and dopamine antagonists.All they have less undesirable side-effects than classical tricyclic antidepressants of the firstgeneration and thymoleptics of the second generation. Thus they are nowadays more often usedas the drugs of the first choice and are therefore met more often in the biological materialanalyzed in toxicological laboratories. This contribution deals with the detection and identificationof paroxetine, sertraline, venlafaxine, mirtazapine, tianeptine, risperidone and quetiapine inurine by thin layer chromatography.

Key words:
thin layer chromatography - antidepressants of the 3rd generation - detection in urine