Hydrophobicity of Klebsiella pneumoniae after Treatment with Ofloxa-cin, Pefloxacin and Tobramycin

Czech version

Authors: A. Hoštacká
Authors‘ workplace: Ústav preventívnej a klinickej medicíny, Bratislava
Published in: Epidemiol. Mikrobiol. Imunol. , 1999, č. 1, s. 28-30
Category:

Overview

The effect of ofloxacin, pefloxacin and tobramycin at subinhibitory concentrations (1/4, 1/8 and 1/16of the MICs) on surface hydrophobicity of the Klebsiella pneumoniae strain was studied. Theantibiotics tested decreased cell surface hydrophobicity in a dose-dependent manner. The mostsignificant reduction of surface hydrophobicity was found after treatment with antibiotics at 1/4 oftheir MICs. Surface hydrophobicity of K. pneumoniae after exposure to these concentrations wasdecreased to 44% (ofloxacin), 50.7% (pefloxacin) and 56.1% (tobramycin) compared with controls.

Key words:
Klebsiella pneumoniae – cell surface hydrophobicity – ofloxacin – pefloxacin – tobramy-cin – subinhibitory concentrations.

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Article was published in

Epidemiology, Microbiology, Immunology

1999 Issue 1