A case report: Acute kidney injury with progression to chronicity in an eldery woman
Authors:
Olga Snížková 1; Karolína Krátká 2; Martin Havrda 2; Ivan Rychlík 2; Mayara Elisa Knížek Bonatto 2; Eva Honsová 1
Authors‘ workplace:
Aeskulab Patologie, k. s., Praha
1; Interní klinika 3. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice Královské Vinohrady, Praha
2
Published in:
Čes.-slov. Patol., 59, 2023, No. 2, p. 80-84
Category:
Original Articles
Overview
Acute renal failure in elderly patients can be caused by a wide spectrum of diseases that usually have a cause outside the kidney. The most common causes include renal impairment as part of ANCA vasculitis, another category includes clonal plasmatic cell disease with light chain cast nephropathy; and there also exists an increasing number of drug-induced tubulointerstial damage. We present a case of iatrogenic less common form of acute failure in a 73-year-old woman, who did not suffer from any serious disease until then. Although the biopsy helped to determine the cause of the failure and thus affect subsequent therapy, the function did not return to the previous state and the patient progressed to CKD G3bA1 with serum creatinine values of around 170-140 μmol/l.
Keywords:
statins – drug toxicity – rhabdomyolysis – acute kidney injury – renal biopsy – renal intratubular casts
Sources
1. Vachek J, Zakiyanov O, Bandúr Š, Tesař V. Akutní poškození ledvin. Kardiol Rev Int Med 2014; 16(1): 57-61.
2. Thomas ME, Blaine C, Dawnay A, et al. The definition of acute kidney injury and its use in practice. Kidney Int 2015; 87: 62-73.
3. Gaut JP, Liapis H. Acute kidney injury pathology and pathophysiology: A retrospective review. Clin Kidney J 2020 Oct 10; 14(2): 526-536.
4. Nickeleit V. Biopsie renálních štěpů: Průvodce spletitými detaily pro získání nejlepších výsledků. Čes.-slov. Patol., 51, 2015, No. 4: 181-186.
5. Vanholder R, Sever MS, Erek E, Lameire N. Rhabdomyolysis. J Am Soc Nephrol 2000 Aug; 11(8): 1553-1561.
6. Gupta A, Thorson P, Penmatsa KR, Gupta P. Rhabdomyolysis: Revisited. Ulster Med J 2021; 90(2): 61-69
7. Torres PA, Helmstetter JA, Kayne AM, Kayne AD. Rhabdomyolysis: Pathogenesis, Diagnosis, and Treatment. Ochsner J. 2015 Spring; 15(1): 58–69.
8. Rojas-Valverde D, Sánchez- Ureña B, Crowe J, Timón R, Olcina GJ. Exertional Rhabdomyolysis and acute kidney injury in endurance sports: A systematic review. Eur J Sport Sci 2021; 21(2): 261-274.
9. Haroun MW, Dieiev V, Kang J, et al. Rhabdomyolysis in COVID-19 Patients: A Retrospective Observational Study. Cureus 2021;13(1): e12552.
10. Kuok CI, Yu Chan WK. Acute kidney injury in pediatric non-traumatic rhabdomyolysis. Pediatr Nephrol 2021; 36(10): 3251-3257.
11. Kruijt N, van den Bersselaar LR, Kamsteeg EJ, et al. The etiology of rhabdomyolysis: an interaction between genetic susceptibility and external triggers. Eur J Neurol 2021; 28(2): 647-659.
12. Huda SA, Yadava S, Kahlown S, Farookqi MS, Bryant S, Russo R. Statin-induced necrotizing autoimmune myopathy, Proc (Bayl Univ Med Cent) 2021; 34(1): 185–186.
13. Furberg CD, Pitt B. Withdrawal of cerivastatin from the world market. Curr Control Trials Cardiovasc Med 2001; 2(5): 205–207.
14. Lima RA, Bezzera da Silva Junior GB, Liborio AB, Daher ED. Acute kidney injury due to Rhabdomyolysis. Saudi J Kidney Dis Transpl 2008; 19(5): 721-729.
15. Huerta-Alardín AL, Varon J, Marik PE. Bench-to-bedside review: Rhabdomyolysis- an overview for clinicians. Crit Care 2005; 9(2): 158-169.
16. Tiniakou E. Statin-Associated Autoimmune Myopathy: Current Perspectives. Ther Clin Risk Manag 2020; 16: 483–492.
17. Christopher-Stine L, Casciola-Rosen LA, Hong G, Chung T, Corse AM, Mammen AL. A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum 2010; 62(9): 2757–2766.
18. Zager RA. Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 1996; 49(2): 314-326
19. Rosenson RS. Current overview of statin-induced myopathy. Am J Med 2004 Mar 15; 116(6): 408-416.
20. Vaughan CJ, Gotto AM Jr. Update on statins. Circulation 2004; 110: 886–892.
21. Reidenberg MM. Statins, lack of energy and ubiquinone. Br J Clin Pharmacol 2005; 59(5): 606–607.
22. Copaja M, Venegas D, Aranguiz P, et al. Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability. Toxicology 2012; 294(1): 42-49
23. Noyes AM, Thompson PD. The effects of statins on exercise and physical activity. J Clin Lipidol 2017; 11(5): 1134-1144.
24. Camerino GN, Tarantino N, Canfora I, De Bellis N, Musumeci O, Pierno S. Statin-Induced Myopathy: Translational Studies from Preclinical to Clinical Evidence. Int J Mol Sci 2021; 22(4): 2070.
25. Dvanajscak Z, Walker PD, Cossey LN, et al. Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders. Kidney Int 2019; 96(6): 1400-1407.
26. Mahmud S, Dernell C, Bal N, et al. Hemoglobin Cast Nephropathy. Kidney Int Rep 2020; 5(9): 1581-1585.
27. Finkel KW, Cohen EP, Shirali A, Abudayyeh A. Paraprotein-Related Kidney Disease: Evaluation and Treatment of Myeloma Cast Nephropathy. Clin J Am Soc Nephrol 2016; 11(12): 2273-2279.
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
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