Histopathological diagnosis of colitis: differential diagnosis and interpretation

Czech version

Authors: Ondřej Fabián ^1,2; Kateřina Kamaradová ^3,4
Authors‘ workplace: Pracoviště klinické a transplantační patologie, Institut klinické a experimentální medicíny, Praha ¹; Ústav patologie a molekulární medicíny 3. LF UK a FTN, Fakultní Thomayerova nemocnice, Praha ²; AeskuLab Patologie k. s., Praha ³; Fingerlandův ústav patologie, Fakultní nemocnice Hradec Králové ⁴
Published in: Čes.-slov. Patol., 58, 2022, No. 1, p. 11-26
Category: Reviews Article

Zánětlivá onemocnění tlustého střeva patří mezi častou problematiku v rutinní bioptické praxi. Jejich interpretace může být náročná s ohledem na omezené a značně překryvné spektrum morfologických změn, kterými se mohou jednotlivá onemocnění manifestovat. Adekvátně posouzená biopsie střevní sliznice však stále představuje důležitý článek multidisciplinárního diagnostického řetězu a rozpoznání základních morfologických vzorců nenádorových střevních onemocnění by tak mělo patřit do výbavy každého patologa. Tento doškolovací text si klade za cíl přiblížit systematický přístup k histopatologickému hodnocení kolitid a zaměřuje se zejména na onemocnění jiná než nespecifické střevní záněty (IBD).

Overview

Non-neoplastic inflammatory conditions of a large bowel mucosa are commonly encountered in bioptic practice. Their interpretation yields many challenges especially due to their limited and often non-specific and overlapping morphological spectrum. However, an accurate assessment of colonic biopsy still represents an important part of multidisciplinary diagnostic process and identification and subsequent interpretation of proper morphological pattern should be in a competence of any routine pathologist. This article provides systematic approach to histopathological assessment of inflammatory diseases of colonic mucosa, focusing mainly on diagnoses other than inflammatory bowel disease (IBD).

Keywords:

Biopsy – Colitis – inflammation – histopathology – differential diagnosis

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