Hyalinizing trabecular tumor of the thyroid gland with transcapsular invasion: a case report
Authors:
Šárka Pokorová; Iva Zambo
Authors‘ workplace:
I. patologicko-anatomický ústav, FN u svaté Anny a LF MU, Brno
Published in:
Čes.-slov. Patol., 63, 2018, No. 4, p. 191-194
Category:
Original Articles
Overview
Hyalinizing trabecular tumor is a rare neoplasm usually with benign clinical behavior. Exceptionally it shows characteristic features of malignant tumors, such as the presence of venous or capsular invasion or distant metastasis. We report the case of 45-years-old female with a palpable nodule in the right lobe of the thyroid gland, 8x8x10 mm in size, well circumscribed, white colored. Histologically it was an encapsulated follicular neoplasm that consisted of medium to large-sized spindle-like to polygonal cells with elongated to round-shaped nuclei and small prominent nucleoli, sporadically with nuclear grooving and intranuclear pseudoinclusions, growing in alveolar to trabecular pattern. The tumor cells showed a distinctive membranous positivity for Ki-67. The tumor was surrounded by a thin fibrous capsule with multifocal transcapsular invasion.
Keywords:
hylinizing trabecular tumor – transcapsular invasion – thyroid gland – Ki-67
Sources
1. Papotti M, Riella P, Montemurro F, Pietribiasi F, Bussolati G. Immunophenotypic heterogeneity of hyalinizing trabecular tumors of the thyroid. Histopathology 1997; 31(6): 525-533.
2. Hirokawa M, Carney JA. Cell membrane and cytoplasmic staining for MIB-1 in hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol 2000; 24(4): 575-578.
3. Lloyd RV, Osamura RY, Klöppel G, Rosai J. WHO Classification of Tumours of Endocrine Organs (4th ed.). In: Bosman FT, Jaffe ES, Lakhani SR, Ohgaki H, eds. World Health Organization Classification of Tumours, WHO Classification of Tumours of Endocrine Organs. Lyon, France: IARC Press; 20174: 73-74.
4. Carney JA, Hirokawa M, Lloyd RV, Papotti M, Sebo TJ. Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol 2008; 32(12): 1877-1889.
5. McCluggage WG, Sloan JM. Hyalinizing trabecular carcinoma of thyroid gland. Histopathology 1996; 28(4): 357-362.
6. Molberg K, Albores-Saavedra J. Hyalinizing trabecular carcinoma of the thyroid gland. Hum Pathol 1994; 25(2): 192-197.
7. Carney JA, Ryan J, Goellner JR. Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol 1987; 11(8): 583-591.
8. Cheung CC, Boerner SL, MacMillan CM, Ramyar LB, Asa SL. Hylinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics. Am J Surrg Pathol 2000; 24(12): 1622-1626.
9. Papotti M, Volante M, Giuliano A, et al. RET/PTC activation in hyalinizing trabecular tumors of the thyroid. Am J Surg Pathol 2000; 24(12): 1615-1621.
10. Sheils OM, O‘eary JJ, Uhlmann V, Lättich K, Sweeney EC. Ret/PTC-1 activation in Hashimoto thyroiditis. Int J Surg Pathol 2000; 8(3): 185-189.
11. Saglietti C, Piana S, La Rosa S, Bongiovanni M. Hyalinizing trabecular tumour of the thyroid: fine-needle aspiration cytological diagnosis and correlation with histology. J Clin Pathol 2017; 70(8): 641-647.
12. Lee S, Hong S, Koo JS. Immunohistochemical subclassification of thyroid tumors with a prominent hyalinizing trabecular pattern. APMIS 2011; 119(8): 529-536.
13. Shikama Y, Osawa T, Yagihashi N, Kurotaki H, Yagihashi S. Neuroendocrine differentiation in hyalinizing trabecular tumor of the thyroid. Virchows Arch 2003; 443(6): 792-796.
14. Leonardo E, Volante M, Barbareschi M, et al. Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: facto r artifact? Appl Immunohistochem Mol Morphol 2007; 15(2): 220-223.
15. Takada N, Hirokawa M, Ohbayashi C, et al. Re-evaluation of MIB-1 immunostaining for diagnosing hyalinizing trabecular tumour of the thyroid: semi-automated techniques with manual antigen retrieval are more accurate than fully automated techniques. Endocr J 2018; 65(2): 239-244.
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2018 Issue 4
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