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Serrated adenomas and carcinomas of the colon


Authors: Alena Chlumská 1,2;  Petr Martínek 2;  Petr Mukenšnabl 1;  Michael Michal 1,2;  Michal Zámečník 3,4
Authors‘ workplace: Šiklův ústav patologie FN, Univerzita Karlova v Plzni, Česká republika 1;  Bioptická laboratoř s. r. o., Plzeň, Česká Republika 2;  Agel a. s., Laboratoř patologie, Nový Jičín, Česká republika 3;  Medirex Group Academy n. o., Bratislava, Slovenská republika 4
Published in: Čes.-slov. Patol., 52, 2016, No. 1, p. 11-14
Category: Reviews Article

Overview

Approximately 5 – 35 % of colorectal carcinomas arise through serrated carcinogenesis. The precursor of such carcinomas are serrated adenomas, which differ from conventional adenomas morphologically as well as genetically. Herein, we provide a basic overview of serrated lesions of the large intestine with the focus on histological diagnosis and molecular biology.

Keywords:
hyperplastic polyp – sessile serrated adenoma – traditional serrated adenoma – serrated carcinoma – serrated carcinogenesis


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