Congenital Granular Cell Epulis: a Case Report

Czech version

Authors: J. Laco
Authors‘ workplace: Lékařská fakulta UK a Fakultní nemocnice, Hradec Králové ; Fingerlandův ústav patologie
Published in: Čes.-slov. Patol., 45, 2009, No. 4, p. 117-119
Category: Original Article

Overview

Congenital granular cell epulis is a rare benign lesion occuring exclusively in newborns as a solitary or multiple swelling of alveolar mucosa of either maxilla or mandible. A case of a female newborn who presented with multiple swellings of both maxillary and mandibular alveolar mucosa measuring up to 10 mm is presented. On 24th postnatal day, the lesions were under general anesthesia excised and sent for microscopic examination, which revealed congenital granular cell epulis. Immunohistochemically, granular cells showed expression of both vimentin and PGP 9.5, whereas the proof of S100 protein and inhibin was negative. The postoperative course was uneventful and follow-up for 8 months showed no local recurrence.

Key words:
congenital granular cell epulis

Sources

1. Barnes, L., Eveson, J.W., Reichart, P., Sidransky, D.: WHO Classification of Tumours. Pathology and Genetics. Head and Neck Tumours. Lyon: IARCPress, 2005, s. 185–186 a s. 198.

2. Eghbalian, F., Monsef, A.: Congenital epulis in the newborn, review of the literature and a case report. J. Pediatr. Hematol. Oncol., 31, 2009, s. 198–199.

3. Kim, E.S., Gross, T.L.: Prenatal ultrasound detection of a congenital epulis in a triple X female fetus: a case report. Prenat. Diagn., 19, 1999, s. 774–776.

4. Nakata, M., Anno, K., Matsumori, L.T. et al.: Prenatal diagnosis of congenital epulis: a case report. Ultrasound Obstet. Gynecol., 20, 2002, s. 627–629.

5. Sakai, V.T., Oliveira, T.M., Silva, T.C., Monetti, A.B., Santos, C.F., Machado, M.A.: Complete spontaneous regression of congenital epulis in a baby by 8 months of age. Int. J. Pediatr. Dent., 17, 2007, s. 309–312.

6. Senoo, H., Iida, S., Kishino, M., Namba, N., Aikawa, T., Kogo, M.: Solitary congenital granular cell lesion of the tongue. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 104, 2007, s. e45–e48.

7. Vered, M., Dobriyan, A., Buchner, A.: Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from granular cell tumor of the adult. Virchows Arch., 454, 2009, s. 303–310.

8. Zuker, R.M., Buenechea, R.: Congenital epulis: review of the literature and case report. J. Oral Maxillofacial. Surg., 51, 1993, s. 1040–1043.

Labels

Anatomical pathology Forensic medical examiner Toxicology

Unusual Clinical Presentation of Hepatic Yolk Sac Tumour in Periappendical Region. A Case Report and Review of the Literature

Mammaglobin Immunostaining in the Differential Diagnosis Between Cutaneous Apocrine Carcinoma and Cutaneous Metastasis from Breast Carcinoma

New Aspects of Tumor Pathobiology

Detection of Regulatory Protein p16/INK4A in the Dysplastic Cervical Squamous Cell Epithelium is a Diagnostic Tool for Carcinoma Prevention

Article was published in

Czecho-Slovak Pathology

2009 Issue 4