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Cutaneous Sarcoidosis during Pegylated Interferon alpha and Ribavirin Treatment of Chronic Hepatitis C – a Case Report


Authors: E. Honsová 1;  E. Sticová 1;  J. Šperl 2
Authors‘ workplace: Pracoviště klinické a transplantační patologie IKEM, Praha 1;  Klinika hepatogastroenterologie IKEM, Praha 2
Published in: Čes.-slov. Patol., 43, 2007, No. 1, p. 27-30
Category: Original Article

Overview

Interferon-induced sarcoidosis is well documented. We report a case of sarcoidosis in a patient with hepatitis C virus infection treated with pegylated interferon alpha and ribavirin. The patient developed cutaneous sarcoidosis about 6 months after beginning of the combination therapy. Spontaneous regression of the lesions was noted after discontinuation of the treatment. Interferon-alpha is known to stimulate T helper cells with a TH-1 profile immune response, which is the key immunologic event of a sarcoid granuloma formation. In addition to its antiviral action, ribavirin also enhanced the TH-1 response. Incidence of drug induced sarcoidosis may be underreported, because many symptoms of sarcoidosis mimic the side-effects of interferon as fever, myalgias, arthralgias, fatigue and symptoms of pulmonary diseases.

Key words:
hepatitis C – interferon-alpha – sarcoidosis


Labels
Anatomical pathology Forensic medical examiner Toxicology
Topics Journals
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