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Anaplastic Carcinoma of the Thyroid Gland with Chondrosarcomatous Component


Authors: J. Laco;  A. Ryška;  P. Čelakovský *
Authors‘ workplace: Fingerlandův ústav patologie, LF UK a FN, Hradec Králové ;  Klinika ušní, nosní a krční, LF UK a FN, Hradec Králové *
Published in: Čes.-slov. Patol., 41, 2005, No. 1, p. 34-37
Category: Original Article

Overview

The case of an 83-year-old female with a history of a two months enlarging goiter is presented.

Clinically, a firm goiter with fixation to surrounding soft tissues was found. Fine needle aspiration cytology was performed with the conclusion of a sarcomatoid variant of anaplastic carcinoma of the thyroid gland; biopsy was recommended. The patient was operated on and died six months after operation with metastatic dissemination in lymphatic nodes and lungs.

Histologically, an invasive high-grade tumor composed of irregular, sometimes bizarre spindled or polygonal cells intermingled with foci of chondroid tissue was seen. The cartilage comprised lobularly arranged chondrocytes with irregular nuclei; bi- or multinucleated chondrocytes were present as well. The diagnosis of thyroid anaplastic carcinoma with chondrosarcomatous component was established. Differential diagnostics of this tumour is discussed.

Key words:
thyroid gland – anaplastic carcinoma – chondrosarcoma


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Anatomical pathology Forensic medical examiner Toxicology
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