Thyroid Peroxidase in Thyroid Gland Differential Diagnosis. The Marker ofMalignancy or Differentiation?
Authors:
I. Kholová 1; A. Ryška 1; M. Ludvíková 3; J. Čáp 2
Authors‘ workplace:
Fingerlandův ústav patologie a 2II. interní klinika Lékařské fakulty Univerzity Karlovy a Fakultní nemocnice, Hradec Králové 3Šiklův patologicko-anatomický ústav Lékařské fakulty Univerzity Karlovy, Plzeň
1
Published in:
Čes.-slov. Patol., , 2004, No. 1, p. 18-21
Category:
Overview
Human thyroid peroxidase (hTPO) is a membrane protein with a key role in the thyroid hormonessynthesis. Loss of hTPO was described in malignant tumours of the thyroid gland. hTPO wastested as a marker of malignancy. Immunohistochemical study of hTPO in 321 thyroid lesions (45malignant tumours, 72 benign tumours, 199 benign non-tumours lesions, and 5 normal thyroidglands) is presented. The sensitivity of hTPO in predicting malignancy in thyroid is 64 %, and thespecificity is 87 %. Thus, hTPO is of limited value in the diagnosis of thyroid malignancy. Theauthors discuss the role of hTPO as a marker of differentiation.
Key words:
human thyroperoxidase - thyroid gland - tumours - marker of malignancy - marker ofdifferentiation - immunohistochemistry
Labels
Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2004 Issue 1
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