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Immunohistochemical Findings in Protracted Cerebral Hypoxia


Authors: I. Bouška 1;  P. Klír 2
Authors‘ workplace: Ústav soudního lékařství UK 2. LF a FNB, Praha 2Subkatedra soudního lékařství IPVZ, Praha 1
Published in: Čes.-slov. Patol., , 2003, No. 1, p. 2-4
Category:

Overview

In the development of secondary changes of brain damage caused by injury, tumour and hypoxiaof different origin with unconsciousness also the activity of the metalloproteinase matrix (MMP)may participate. Their activation occurs first in the vascular wall which they damage and it maybe assumed that MMP potentiate thus secondary changes in the sense of interfering with thehaematoencephalic barrier with development of vasogenic cerebral oedema. In the cells of thevascular wall and in glial elements already after two days MMP-2 and MMP-9 activity was proved.While in focal injuries the findings were in particular at the site of contusion foci, in prolongedhypoxia for various reasons these changes were diffuse.

Key words:
metalloproteinase matrix - cerebral hypoxia - secondary cerebral changes

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Labels
Anatomical pathology Forensic medical examiner Toxicology

Article was published in

Czecho-Slovak Pathology


2003 Issue 1

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