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Lipomatous Hamartomas of Brain -Malformations of the Subarachnoid Space


Authors: J. Zámečník;  M. Kynčl
Published in: Čes.-slov. Patol., , 2001, No. 4, p. 163-167
Category:

Overview

Lipomatous hamartomas are rare disorders affecting the central nervous system. In our report,two observations of this disorder are presented. Both are interhemispheric in location and areassociated with a complete agenesis of the corpus callosum, while having different histologicalstructures. In our first patient, the intracranial formation caused refractory seizures, was partially surgically removed, and a biopsy was performed. Light microscopic examination disclosed thepresence of a highly vascularized mature adipose tissue with numerous calcifications. The secondcase was an incidental finding at autopsy. Microscopically, we found adipose tissue together withnumerous foci of hemopoiesis and structures of lamelar bone. In both cases, the indistinct demarcation of the collagenous capsule from the surrounding brain tissue and the continuity of thehamartoma with the leptomeninges were striking.In recent findings about the development of meninges and brain commissures, the origin of thisdisorder is explained as a defective resorption of the embryonic meninx primitiva. This disorderthen causes other developmental aberrations of the brain, which are often found in association.The varying microscopic pattern of these disorders can also be satisfactorily explained by theirorigin in the primitive meninx, which is formed from both mesenchyme and neuroectoderm.

Key words:
hamartoma - intracranial lipoma - corpus callosum - subarachnoid spaces

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Anatomical pathology Forensic medical examiner Toxicology
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