Vaccination of children against COVID-19
Authors:
Cabrnochová Hana 1,2
Authors‘ workplace:
Očkovací centrum pro děti, Pediatrická klinika, 1. lékařská fakulta Univerzity Karlovy, Fakultní Thomayerova nemocnice, Praha
1; Ordinace PLDD, Praha 4
2
Published in:
Čes-slov Pediat 2023; 78 (Supplementum 1): 7-12.
Category:
Comprehensive Report
doi:
https://doi.org/10.55095/CSPediatrie2023/026
Overview
The risk of severe covid-19 is lower than in adults, most cases of covid-19 in children are asymptomatic or mild. With regard to the number of reported cases in children, we may encounter complicated cases, the need for hospitalization and intensive care stays. A rare complication of covid-19 in children is a multisystem inflammatory disease (referred to as MIS-C or PIMS-TS), which arises as a post-infectious complication of covid-19. As an additional complication in children, long-term problems called „long-covid“ may occur after the disease. Vaccination against covid-19 is recommended for all children, in case of illness vaccination is not contraindicated, it is possible to postpone it for 3-6 months after the disease. Neither natural infection nor vaccination provides long-term immunity. Vaccination can reduce the risk of reinfection and, above all, severe courses of the disease.
Vaccination against covid-19 is indicated for all children aged 6 months and over, infants younger than 6 months can be protected by vaccinating the mother during pregnancy In childhood, mRNA vaccines are predominantly used. Their safety has been unequivocally proven. Billions of adults were vaccinated before childhood vaccination began, and millions of children are now safely vaccinated.
In the Czech Republic, vaccination coverage in children reached 49.1% in the age category 12-15 years and 7.1% in the age category 5-11 years (administration of at least one dose of vaccine) as of 27.10.2022. The vaccination rate for the age category of children 12-17 years was 54.3% as of 15.2.2023, while for the youngest children 5-11 years the number remains the same as at the end of 2022.
Keywords:
Vaccines – Safety – efficacy – COVID-19 in children – vaccination of children – adverse effects of vaccination – contraindications.
Sources
1. Wang L, Berger NA, Kaelber DC, et al. Incidence rates and clinical outcomes of SARS-CoV-2 infection with the omicron and delta variants in children younger than 5 years in the US. JAMA Pediatr 2022; 176(8): 811–813.
2. H arapan BN, Yoo HJ. Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19). J Neurol 2021; 268: 3059–3071.
3. A ntoon JW, Hall M, Howard LM, et al. COVID-19 and acute neurologic complications in children. Pediatrics 2022; 150.
4. D avid J, Hradsky O, Jabandziev P, et al. Impact of SARS-CoV-2 variants on the incidence of paediatric inflammatory multisystem syndrome (PIMS-TS). J Paediatr Child Health 2022; 58(10): 1901–1903.
5. L opez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, et al. Long-COVID in children and adolescents: a systematic review and meta-analyses. Sci Rep 2022; 12(1): 9950.
6. G ottesman BL, Yu J, Tanaka C, et al. Incidence of new-onset type 1 diabetes among US children during the COVID-19 global pandemic. JAMA Pediatr 2022; 176: 414–415.
7. M inisterstvo zdravotnictví České republiky. Onemocnění aktuálně – COVID- 19. Datové sady. [online]. 2023. Dostupné z: https://onemocneni-aktualne. mzcr.cz/api/v2/covid-19
8. F laxman S, Whittaker C, Semenova E, et al. Assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US. JAMA Netw Open 2023; 6(1): e2253590.
9. K han FL, Nguyen JL, Singh TG, et al. Estimated BNT162b2 vaccine effectiveness against infection with delta and omicron variants among US children 5 to 11 years of age. JAMA Netw Open 2022; 5: e2246915–e2246915.
10. Mallapaty S. COVID jabs for kids: they’re safe and they work — so why is uptake so patchy? Nature 2022; 610: 246–8.
11. Castelli JM, Rearte A, Olszevicki S, et al. Effectiveness of mRNA-1273, BNT162b2, and BBIBP-CorV vaccines against infection and mortality in children in Argentina, during predominance of delta and omicron covid-19 variants: test negative, case-control study. BMJ 2022; 379.
12. Chemaitelly H, AlMukdad S, Ayoub HH, et al. Covid-19 vaccine protection among children and adolescents in Qatar. N Engl J Med 2022; 387: 1865– 1876.
13. H olm M, Espenhain L, Glenthøj J, et al. Risk and phenotype of multisystem inflammatory syndrome in vaccinated and unvaccinated danish children before and during the omicron wave. JAMA Pediatr 2022; 176: 821–823.
14. L ai FTT, Chan EWW, Huang L, et al. Prognosis of myocarditis developing after mRNA COVID-19 vaccination compared with viral myocarditis. J Am Coll Cardiol 2022; 80: 2255–2265.
15. E lias MD, Truong DT, Oster ME, et al. Examination of adverse reactions after COVID-19 vaccination among patients with a history of multisystem inflammatory syndrome in children. JAMA Netw Open 2023; 6: e2248987– e2248987.
16. G ruber WC, Jansen KU; C4591001 Clinical Trial Group. Safety and Efficacy of the BNT162b2 mRNA Covid-19 vaccine through 6 months. N Engl J Med 2021; 385(19): 1761–1773.
17. A nderson EJ, Creech CB, Berthaud V, et al. Evaluation of mRNA-1273 vaccine in children 6 months to 5 years of age. N Engl J Med 2022; 387: 1673–1687.
18. P fizer and BioNTech Announce Updated COVID-19 Vaccine Data Supporting Efficacy in Children 6 Months through 4 Years of Age. Dostupné z: www.pfizer.com
19. ČVS. Doporučení České vakcinologické společnosti ČLS JEP k očkování proti onemocnění covid-19 (11/2022). 2022. Dostupné z: https://www.vakcinace. eu
20. M inisterstvo zdravotnictví ČR. Dostupné z: https://www.mzcr.cz/tiskove- -centrum-mz/denni-prehled-dat-k-ockovani-proti-covid-19-k-15-2-2023
21. ECDC. Dostupné z: https://www.ecdc.europa.eu/sites/default/files/documents/ COVID-19-vaccination-strategies-march-2023.pdf
Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2023 Issue Supplementum 1
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