Secondary malignancies in pediatric patients after hematopoietic stem cell transplantation
Authors:
L. Géczová 1,2; S. Šufliarska 2; J. Horáková 2; B. Mladosievičová 1; doc. MUDr. Prednosta Ústavu M. Bernadič, CSc.; mim. prof.
Authors‘ workplace:
Oddelenie klinickej patofyziológie, Ústav patologickej fyziológie LFUK, Bratislavavedúca doc. MUDr. B. Mladosievičová, CSc.
1; Klinika detskej hematológie a onkológie LFUK a DFNsP, Transplantačná jednotka kostnej drene, Bratislavaprednostka doc. MUDr. E. Kaiserová
2
Published in:
Čes-slov Pediat 2013; 68 (1): 49-56.
Category:
Review
Overview
There is an increased risk of early and late complications following allogeneic hematopoietic stem cell transplantation despite its demonstrated success in children. Among the life-threatening complications, which occur between 6 months and several years following the transplantation and the first diagnosis of malignancy, are secondary leukemias or secondary solid tumours.
In this review we summarise relevant genetic polymorphisms associated with increased risk of secondary malignancies. Additionally, we pay specific attention to screening, management and prophylaxis in pediatric patients following hematopoietic stem cell transplantation.
Key words:
hematopoietic stem cell transplantation, secondary malignancies, genetic polymorphisms
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Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2013 Issue 1
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