Reactive hyperemic index and endothelial dysfunction in children – pilot study
Authors:
P. Jehlička; M. Huml; T. Votava; R. Pomahačová; J. Kobr
Authors‘ workplace:
Dětská klinika FN, Univerzita Karlova v Praze, Lékařská fakulta v Plzni
přednosta doc. MUDr. J. Kobr, PhD.
Published in:
Čes-slov Pediat 2011; 66 (2): 75-78.
Category:
Original Papers
Overview
The objective of this pilot study was to evaluate endothelial dysfunction (ED) in children with type 1 diabetes mellitus (T1DM) and in children following treatment for acute lymphoblastic leukemia (ALL). This data was then compared with healthy controls (HC). An EndoPAT 2000® recorder was used for the determination of the Reactive Hyperemia Index (RHI) by measuring postocclusive endothelium-dependent changes in vascular tone (PAT) in subjects’ fingertips.
A cohort of 35 eligible study participants comprising of 14 T1DM and 11 ALL patients were matched with a control group of 10 healthy children. Significantly lower RHI were revealed in T1DM patients in comparison with HC (1.50±0.56 vs. 1.99±0.68, p≤0.05), implying impaired endothelial-dependent dilation. ALL subjects tended to have lower RHI compared with HC (1.58±0.48 vs. 1.99±0.68, p>0.05). RHI brings an advantage compared to the other non-invasive methods.
Our pilot study showed that RHI might be a promising method in assessing ED in children with a high risk of premature atherosclerosis.
Key words:
endothelial dysfunction, children, RHI, T1DM, ALL
Sources
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2011 Issue 2
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