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Secondary Syphilis with a Less Common Histological Finding. Case report


Authors: L. Drlík 1;  Z. Drlík 1,2,3;  L. Pock 4
Authors‘ workplace: Dermatologická ambulance Mohelnice 1;  Klinika chorob kožních a pohlavních, Fakultní nemocnice Olomouc přednosta odborný asistent Martin Tichý, Ph. D. 2;  Lékařská fakulta Univerzity Palackého Olomouc 3;  Bioptická laboratoř Plzeň, s. r. o. 4
Published in: Čes-slov Derm, 98, 2023, No. 6, p. 296-299
Category: Case Reports

Overview

A 57-year-old female patient was affected by a sudden, generalized, non-itchy exanthema affecting mainlythe trunk. Given the history of antibiotic use and previous allergic drug reactions, the disease was considered toxoallergic dermatitis. Histological findings showed an increased number of plasma cells. Subsequent immunohistochemical examination demonstrated the presence of isolated treponems. Theauthors present an overview of the histological findings accompanying secondary syphilis.

Keywords:

secondary syphilis – histopathology – plasma cells


Sources
  1. CETKOVSKÝ, M., KOJANOVÁ, M., DŮRA, M. et al. Generalizované papuly a noduly. Čes-slov Derm, 2023, 98, 1, p. 26–29.
  2. CORREIA, E., GLEASON, L., KRISHNASAMY, S. et al. Secondary syphilis mimicking marginal zone B-cell lymphoma. J Am Acad Dermatol., 2021,15(20), p. 50–53.
  3. ELSTON, D. M., FERRINGER, T., KO, C. J. et al. Dermatopathology, 2nd ed. Elsevier Saunders, 2014, p. 267–268.
  4. ENQELKENS, H. J., TEN KATE, F. J., VUZEVSKI, V. D. et al. Primary and secondary syphilis: a histopathological study. Int J STD AIDS, 1991, 2(4), p. 280–284.
  5. FLAMM, A., ALCOCER, V. M., KAZLOUSKAYA, V. et al. Histopathologic features distinguishing secondary syphilis from its mimickers. J Am Acad Dermatol., 2020, 82(1), p. 156–160.
  6. FLAMM, A., PARIKH, K., XIE, Q. et al. Histologic features of secondary syphilis: A multicenter retrospective review. J Am Acad Dermatol., 2015, 73(6), p. 1025–1030.
  7. GLATZ, M., ASCHERMANN, Y., KERL, K. et al. Nodular secondary syphilis in a woman. BMJ Case Rep., 2013, bcr2013009130. doi: 10.1136/bcr-2013-009130. PMID: 23661656; PMCID: PMC3669848.
  8. LIU, X. K, LI, J. Histologic Features of Secondary Syphilis. Dermatology, 2020, 236(2), p. 145–150.
  9. MARTÍN-EZGUERRA, G., FERNANDEZ-CASADO, A., BARCO, D. et al. Treponema pallidum distribution patterns in mucocutaneous lesions of primary and secondary syphilis: an immunohistochemical and ultrastructural study. Hum Pathol., 2009, 40(5), p. 624–630.
  10. SEZER, E., LUZAR, B., CALONJE, E. Secondary syphilis with an interstitial granuloma annulare-like histopathologic pattern. J Cutan Pathol.. 2011, 38(5), p. 439–442.

Do redakce došlo dne 14. 9. 2023.

Adresa pro korespondenci:
MUDr. Lubomír Drlík Dermatologická ambulance
Nádražní 35
789 85 Mohelnice
e-mail:
mudr.drlik@email.cz

 
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Dermatology & STDs Paediatric dermatology & STDs
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