#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Development of Antimicrobial Resistance of Neisseria Gonorrhoeae in The Years 2015–2020 in Prague in the European Context


Authors: B. Bížová 1;  M. Kojanová 2;  M. Slováčková 3;  F. Rob 1
Authors‘ workplace: Dermatovenerologická klinika 2. LF UK a Fakultní nemocnice Bulovka, Praha, přednosta doc. MUDr. Filip Rob, Ph. D. 1;  Dermatovenerologická klinika 1. LF UK a Všeobecné fakultní nemocnice, Praha, přednosta prof. MUDr. Jiří Štork, CSc. 2;  Ústav lékařské biochemie a laboratorní diagnostiky Všeobecné fakultní nemocnice a 1. LF UK Praha, přednosta prof. MUDr. Tomáš Zima, DrSc., MBA 3
Published in: Čes-slov Derm, 97, 2022, No. 4, p. 158-163
Category: Pharmacologyand Therapy, Clinical Trials

Overview

With over 86 million cases of gonorrhea are diagnosed worldwide each year. Due to increasing antimicrobial resistance, N. gonorrhea is becoming a risk. The incidence of gonorrhea is increasing not only in Europe, but also in the Czech Republic, most cases are reported in men having sex with men. Antimicrobial sensitivity is tested most often from urogenital infections and is processed internationally in the Euro-GASP project. For commonly administered azithromycin, resistance spread in Europe from 7.1% in 2015 to 13.3% in 2018; in the Czech Republic, according to data from the General Faculty Hospital (VFN) and the Bulovka University Hospital (FNB), it increased from 5.9% in 2015 to 27.3% in 2020. Resistance to ciprofloxacin is around 50% in Europe, 35-38% in the Czech Republic. Susceptibility to tetracycline is improving in VFN and FNB from 32.2% in 2015 to 23.2% in 2020. In the Czech Republic, a single case of resistance to cefixime was discovered in 2018, none has yet been described for ceftriaxone.

Keywords:

Epidemiology – Antibiotic resistance – Gonorrhea


Sources

1. CHOW, E. P. F., WILLIAMSON, D. A., HOCKING J. S. et al. Antiseptic mouthwash for gonorrhoea prevention (OMEGA): a randomised, double-blind, parallel- group, multicentre trial. The Lancet Infectious Diseases, 2021, 21(5), p. 647–656. ISSN 14733099. doi: 10.1016/S1473-3099(20)30704-0.

2. COLE, M. J., QUINTEN, C., JACOBSSON S. et al. The European gonococcal antimicrobial surveillance programme (Euro-GASP) appropriately reflects the antimicrobial resistance situation for Neisseria gonorrhoeae in the European Union/European Economic Area. BMC Infect Dis., 2019, 19(1), p. 1040. doi: 10.1186/s12879-019-4631-x.

3. European Centre for Disease Prevention and Control. Gonorrhoea. In: ECDC. Annual epidemiological report for 2015. Stockholm: ECDC; 2017.

4. European Centre for Disease Prevention and Control. Gonorrhoea. In: ECDC. Annual epidemiological report for 2018. Stockholm: ECDC; 2019.

5. European Centre for Disease Prevention and Control. Gonococcal antimicrobial susceptibility surveillance in Europe, 2015. Stockholm: ECDC; 2017.

6. European Centre for Disease Prevention and Control. Gonococcal antimicrobial susceptibility surveillance in Europe – Results summary 2018. Stockholm: ECDC; 2020.

7. FIFER, H., SAUNDERS, J., SONI, S. et al. 2018 UK national guideline for the management of infection with Neisseria gonorrhoeae. Int J STD AIDS, 2020, 31, p. 4–15.

8. LIN, E. Y., ADAMSON, P. C., KLAUSNER, J. D. Epidemiology, Treatments, and Vaccine Development for Antimicrobial-Resistant Neisseria gonorrhoeae: Current Strategies and Future Directions. Drugs, 2021, 81(10), p. 1153–1169. ISSN 0012-6667. doi: 10.1007/s40265-021-01530-0.

9. QUILLIN, S. J., SEIFERT, H. S. Neisseria gonorrhoeae host adaptation and pathogenesis. Nature Reviews Microbiology, 2018, 16(4), p. 226–240. ISSN 1740- 1526. doi: 10.1038/nrmicro.2017.169.

10. Ústav zdravotnických informací a statistiky ČR. Registr pohlavních nemocí (RPN). [online]. [cit. 2021-8-25]. Dostupné na www: https://www. uzis.cz/index.php?pg=registry-sber-dat--ochrana- verejneho-zdravi--registr-pohlavnich-nemoci.

11. ROB, F., KLUBALOVÁ, B., NYČOVÁ, E. et al. Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea: a randomized controlled trial. Clinical Microbiology and Infection, 2020, 26(2), p. 207–212. ISSN 1198743X. doi: 10.1016/j.cmi.2019.08.004.

12. ROWLEY, J., VANDER HOORN, S., KORENROMP, E. et al. Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016. Bull World Health Organ., 2019, 97(8), p. 548–562. doi: 10.2471/BLT.18.228486.

13. ST. CYR, S., BARBEE, L., WORKOWSKI, K. A. et al. Update to CDC‘s Treatment Guidelines for Gonococcal Infection, 2020. MMWR. Morbidity and Mortality Weekly Report [online]. 2020, 69(50), p. 1911–1916 [cit. 2022-02- 07]. ISSN 0149-2195. doi: 10.15585/mmwr.mm6950a6.

14. UNEMO, M., ISON, C. Gonorrhoea. In: UNEMO, M. et al. Laboratory diagnosis of sexually transmitted infections, including human immunodeficiency virus. 2nd ed. Geneva, Switzerland: World Health Organization, 2013, p. 21–54.

15. UNEMO, M., ROSS, J., SERWIN, A. B. et al. 2020 European guideline for the diagnosis and treatment of gonorrhoea in adults [published online ahead of print, 2020 Oct 29]. Int J STD AIDS, 2020, 956462420949126. doi: 10.1177/ 0956462420949126.

16. UNEMO, M., SEIFERT, H. S., HOOK, E. W. et al. Gonorrhoea. Nature Reviews Disease Primers. 2019, 5(1). ISSN 2056-676X. doi: 10.1038/s41572-019-0128-6.

17. VAN DIJCK, C., TSOUMANIS, A., ROTSAERT, A. et al. Antibacterial mouthwash to prevent sexually transmitted infections in men who have sex with men taking HIV pre-exposure prophylaxis (PReGo): a randomised, placebo-controlled, crossover trial. The Lancet Infectious Diseases, 2021, 21(5), p. 657–667. ISSN 14733099. doi: 10.1016/S1473- 3099(20)30778-7.

18. World Health Organization. Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics. Geneva: WHO Press; 2017. p. 1–7.

19. World Health Organization. WHO guidelines for the treatment of Neisseria gonorrhoeae. Geneva: World Health Organization; 2016. Dostupné na www: https://apps.who.int/iris/handle/ 10665/246114.

20. ZÁKOUCKÁ, H. Kapavka – stručné připomenutí aktuálního problému. Zprávy EM (SZÚ, Praha), 2009, 18(12), s. 371–374.

21. ZÁKOUCKÁ, H. Sexually transmitted infections: a modern approach to diagnosis. Dermatologie pro Praxi, 2020, 14(1), s. 10–16.

Labels
Dermatology & STDs Paediatric dermatology & STDs
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#