Diffuse Plane Normolipemic Xanthoma. Case Report
Authors:
D. Suchánková; M. Arenbergerová 1; E. Sticová 2; P. Arenberger 1
Authors‘ workplace:
Dermatovenerologická klinika 3. LF UK a FNKV, Praha, přednosta prof. MUDr. Petr Arenberger, DrSc., MBA
1; Ústav patologie 3. LF UK a FNKV, Praha, přednosta doc. MUDr. Tomáš Jirásek, Ph. D.
2
Published in:
Čes-slov Derm, 93, 2018, No. 4, p. 137-140
Category:
Case Reports
Overview
Diffuse plane normolipemic xanthoma is a rare disease of unknown etiology with normal levels of lipids in the blood. Association with hematologic malignancies, especially with multiple myeloma, has been described. The authors present a case of 69-year-old patient with three malignant diseases including multiple myeloma with diffuse skin xanhoma. The pacient underwent combination chemotherapy of the symptomatic multiple myeloma, which stabilized the hematologic disease but condition of the skin lesions remained further in progression. The case interpretation points out the importance of interdisciplinary cooperation and difficult therapeutic management of this disease.
Key words:
diffuse plane normolipemic xanthoma – xanthoma planum diffusum – xanthoma – monoclonal gammopathy – multiple myeloma
Sources
1. BOLOGNIA, J. L., JORIZZO, J. L., SCHAFFER, J. V. Dermatology. 3rd edition: Philadelphia: Elsevier Saunders, 2012, p. 1552–1553
2. COHEN, Y. K, ELPERN, D. J. Diffuse normolipemic plane xanthoma associated with monoclonal gammopathy. Dermatol. Pract. Concept., 2015, 5(4), p. 65–67.
3. KOÇAK, M., KELEŞ, H., YAKARYILMAZ, F., BOZDOĞAN, Ö., GÜLITER, S. Diffuse plane xanthomatosis in a patient with Budd-Chiari syndrome and monoclonal gammopathy. Indian. J. Dermatol., 2009, 54(4), p. 369–371.
4. LORENZ, S., HOHENLEUTNER, S., HOHENLEUTNER, U., LANDTHALER, M. Treatment of Diffuse Plane Xanthoma of the Face With the Erbium:YAG Laser. Arch. Dermatol., 2001, 137(11), p. 1413–1415.
5. MARCOVAL, J., MORENO, A., BORDAS, X. et al. Diffuse plane xanthoma: clinicopathologic study of 8 cases. J. Am. Acad. Dermatol., 1998, 39, p. 439–42.
6. MILLARD, L. G. Generalized plane xanthomata with macroglobulinaemia. Proc R Soc Med., 1973, 66(4), p. 325–326.
7. MIYAGAWA, F., FUKUMOTO, T., KOBAYASHI, N., ASADA, H. Successful Treatment of Diffuse Normolipemic Plane Xanthoma with Probucol. Case Rep Dermatol., 2013, 5(2), p. 148–151.
8. SCHLOSS, E., BROWN, J. Sézary’s syndrome and generalized plane xanthoma. Can. Med. Assoc. J., 1978, 118(4), p. 377–378.
9. YAMAMOTO, A. A unique antilipidemic drug – probucol. J. Atheroscler. Thromb., 2008, 15, p. 304–305.
Labels
Dermatology & STDs Paediatric dermatology & STDsArticle was published in
Czech-Slovak Dermatology
2018 Issue 4
Most read in this issue
- Biopsy in Dermatovenereology
- Papulonecrotic Tuberculide. Case Report
- Diffuse Plane Normolipemic Xanthoma. Case Report