Retinoids in Dermatology

Czech version

Authors: N. Benáková ^1,2; V. Vašků ³
Authors‘ workplace: Dermatovenerologická klinika 1. LF UK a VFN Praha přednosta prof. MUDr. Jiří Štork, CSc. ¹; Dermato-alergologická ordinace ImmunoFlow Praha vedoucí pracoviště MUDr. Matrin Fuchs ²; Dermatovenerologická klinika LF MU Brno přednosta prof. MUDr. Vladimír Vašků, CSc. ³
Published in: Čes-slov Derm, 92, 2017, No. 3, p. 111-122
Category: Reviews (Continuing Medical Education)

Overview

The authors discuss the history of the development and classification of retinoids, their pharmacodynamic properties, including the biological potential for the treatment. The overview discusses the pharmacological and clinical characteristics of topical and systemic retinoids, their availability and current conditions of reimbursement in the Czech Republic. The main part is the use of retinoids in practice, more in detail the use of three systemic retinoids – acitretin, bexarotene and isotretinoin. The tables show the standard indications as well as the less common possibilities of their use, contraindications, dosing and current recommendations for clinical and laboratory examinations before and during treatment and follow-up. Detailed side effects and measures for their prevention, alleviation and early recognition are discussed. The advantages of retinoids such as the absence of immunosuppression, the possibility of combination therapy, the minimal drug interactions, and a generally good safety profile that outweight the potential risks that allow their use for long-term maintenance therapy, are also emphasized.

Key words:
retinoids – systemic therapy – practical use and perspective in dermatology

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Dermatology & STDs Paediatric dermatology & STDs

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Article was published in

Czech-Slovak Dermatology

2017 Issue 3