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Psoriasis-like Skin Reactions during TNF-α Blockers Therapy


Authors: P. Kozub 1;  Z. Szép 2;  M. Šimaljaková 1
Authors‘ workplace: Dermatovenerologická klinika LF UK a UN v Bratislave prednosta prof. MUDr. Mária Šimaljaková, PhD. 1;  CYTOPATHOS, spol. s r. o., laboratórium bioptickej a cytologickej diagnostiky, Bratislava prednosta doc. MUDr. Dušan Daniš, CSc. 2
Published in: Čes-slov Derm, 86, 2011, No. 4, p. 186-192
Category: Pharmacologyand Therapy, Clinical Trials

Overview

Biological therapy with TNF-α blockers represents the top in the management of some inflammatory diseases, in which cytokine TNF-α play a pathogenetical role, in dermatology, rheumatology and gastroenterology. These diseases include psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis, Crohn’s disease and ulcerative colitis. TNF-α blockers have been successfully used in the therapy of psoriasis vulgaris since 2004. However, the paradoxical skin reactions including psoriasis-like eruptions appear during therapy with etanercept, adalimumab and infliximab in various intervals of treatment independently of the indication. Article reviews the psoriasis-like reactions occurring during TNF-α inhibitors therapy and the possibilities of their treatment.

Key words:
TNF-α blockers – psoriasis-like eruptions


Sources

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