Immunofluorescence in Dermatology
Authors:
H. Jedličková
Authors‘ workplace:
Dermatovenerologická klinika FN u sv. Anny v Brně a LF MU
Published in:
Čes-slov Derm, 86, 2011, No. 4, p. 175-184
Category:
Reviews (Continuing Medical Education)
Overview
Immunofluorescence methods have been used in medical research and diagnostics for more than 50 years. In dermatology, direct and indirect immunofluorescence methods are mainly used in diagnostics of immunobullous and connective tissue diseases. The review summarizes the basic diagnostic possibilities and common findings in these disesases, and other uses, including modern applications of immunofluorescence methods.
Key words:
immunofluorescence – dermatology – bullous dermatoses – connective tissue disorders –methods
Sources
1. ALAHLAFI, A. M., WORDSWORTH, P., WOJNAROWSKA, F. The lupus band: do the autoantibodies target collagen VII? Br. J. Dermatol., 2004, 150, p. 504–510.
2. BEUTNER, E. H., JORDON, R. E. Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining. Proc. Soc. Exp. Biol Med., 1964, 117, p. 505–510.
3. BIELSA, I. New Antibodies in Dermatomyositis. Actas Dermosifiliogr., 2009, 100, p. 182–189.
4. BURNHAM, T. K., NEBLETT, T. R., FINE, G. Application of fluorescent antibody technique to the investigation of lupus erythematosus and various dermatoses. J. Invest. Dermatol., 1963, 41, p. 451–456.
5. BRUCH-GERHARZ, D., HERTL, M., RUZICKA, T. Mucous membrane pemphigoid: clinical aspects, immunopathological features and therapy. Eur. J. Dermatol., 2007, 17, p. 191–200.
6. CETKOVSKÁ, P. Autoimunitní bulózní dermatózy. Čes-slov. Derm., 2006, 81, p. 188–196.
7. DAMOISEAUX, J., STELLER, U., BUSCHTEZ, M., VAESSEN, M., ROSEMANN, A., VAN PAASSEN, P., STÖCKER, W., FECHNER, K., TERVAERT, J. W. EUROPLUS ANCA BIOCHIP mosaic: PR3 and MPO antigen microdots improve the laboratory diagnostics of ANCA-associated vasculitis. J. Immunol. Methods., 2009, 348, p. 67–73.
8. FRIOU, G. J. Clinical application of lupus serum. Nucleoprotein reaction using fluorescent antibody technique. J. Clin. Invest.,1957, 36, p. 890.
9. FRY, L. Dermatitis herpetiformis: problems, progress and prospects. Eur. J. Dermatol., 2002, 12, p. 523–531.
10. HALAGOVEC, A., JAUTOVÁ, J., ROSOCHA, J., GARZANIČ, V., ANDRAŠKO, J., MARTINÁSKOVÁ, K., KAMPE, T. Súčasné možnosti imunohistochemického diagnostikovania autoimunitných bulóznych ochorení v zóne epidermálnej bazálnej membrány. Čes-slov. Derm., 2002, 77, p. 245–251.
11. HONOMICHLOVÁ, P., PIZINGER, K., CETKOVSKÁ, P. Paraneoplastický pemfigus. Čes-slov. Derm., 2004, 5, p. 173–175.
12. IIDA, K., SUEKI, H., OHYAMA, B., ISHII, N., HASHIMOTO, T. A Unique Case of Intra-Epidermal Neutrophilic Dermatosis-Type IgA Pemphigus Presenting with Subcorneal Pustules. Dermatology, 2011, 222, p. 15–19.
13. JEDLIČKOVÁ, H., NIEDERMEIER, A., ZGAŽAROVÁ, S., HERTL, M. Brunsting-Perry Pemphigoid of the Scalp with Antibodies against Laminin 332. Dermatology., 2011 [Epub ahead of print].
14. JEDLIČKOVÁ, H., RAČOVSKÁ, J., NIEDERMEIER, A., FEIT, J., HERTL, M. Anti-basement membrane zone antibodies in elderly patients with pruritic disorders and diabetes mellitus. Eur. J. Dermatol., 2008, 18, p. 534–538.
15. JORDON, R. E., BEUTNER, E. H., WITEBSKY, E., BLUMENTAL, G., HALE, W. L., LEVER, W. F. Basement zone antibodies in bullous pemphigoid. JAMA, 1967, 200, p. 751–756.
16. KORMAN, N. J., WATSON, R. D. Immune –mediated subepidermal blistering diseases of the mucous membranes: improving the detection of circulating autoantibodies by the use of concentrated serum samples. Arch. Dermatol., 1996, 132, p. 1194–1198.
17. KRATOCHVIL, F. Využití a klinický význam imunofluorescenčních metod v dermatologii. Brno: Opuscula dermatovenerologica 101, Sborník prací Lékařské fakulty v Brně, 1988.
18. VAN DER MEER, J. B. Granular deposits of immunoglobulins in the skin of patients with dermatitis herpetiformis. An immunofluorescent study. Br. J. Dermatol., 1969, 81, p. 493–503.
19. MEGAHED, M. Paraneoplastic pemphigus. In: Histopathology of blistering diseases. Berlin: Springer 2004, p. 103–108.
20. MOREY, A. L., MURALI, R., MCCARTHY, S. W., MANN, G. J., SCOLYER, R. A. Diagnosis of cutaneous melanocytic tumours by four-colour fluorescence in situ hybridisation Pathology., 2009, 41, p. 383–387.
21. MUTASIM, D. F., ADAMS, B. B. Immunofluorescence in dermatology. J. Am. Acad. Dermatol., 2001, 45, p. 803–822.
22. ROSE, C., ARMBRUSTER, F. P., RUPPERT, J., IGL, B-W., ZILLIKENS, D., SHIMANOVICH, I. Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet. J. Am. Acad. Dermatol., 2009, 61, p. 39–43.
23. ROSE, C., ZILLIKENS, D. Dermatitis Herpetiformis Duhring. In: Autoimmune diseases of the skin. Hertl, M. (ed.) Wien: Springer, 2005, 2. angl. Vydání, p. 95–108.
24. SALAVEC, M. Diagnostika a terapie autoimunitních puchýřnatých chorob. Dermatol. praxi., 2010, 4, p. 148–155.
25. SALAVEC, M., NOŽICKA, Z., ROZSÍVALOVÁ, V., PAVLÁTOVÁ, J. The immunofluorescence evaluation of some subepidermal bullous diseases by use of NaCl-split skin. Sb. Ved. Pr. LF UK, Hradec Králové. 1994, 37, p. 67–71.
26. SALAVEC, M. et al. IgA bulózní dermatóza u dětí. Derma., 2009, 1, p. 15–19.
27. SHIBESHI, D., JARZABEK- CHORZELSKA, M., JABLOŃSKA, S., CHORZELSKI, T. Immunopathologic findings in systemic sclerosis patients: clinical and immunopathologic relationships. Int. J. Dermatol., 1989, 28, p. 650–656.
28. VLAŠÍN, Z. Puchýřnatá onemocnění skupiny pemfigu a pemfigoidu. Praha: Avicenum, 1978.
29. VLAŠÍN, Z., HLUBINKA, M., JEDLIČKOVÁ, H., RULCOVÁ J., LOKAJ, J. Nejběžnější imunofluorescenční obrazy kožních chorob. Klin. imunológia a alergológia, 2000, 10, p. 5–8.
30. VLAŠÍN Z., HLUBINKA M., POKORNÁ, J., JEDLIČKOVÁ, H., LOKAJ J. Diagnostické využití metody nepřímé imunofluorescence v dermatologii. Čes-slov. Derm., 2000, 75, p. 75–79.
31. VLAŠÍN, Z., HLUBINKA, M., RULCOVÁ, J. Výsledky imunohistologického vyšetřování nepostižené (před sluncem chráněné) kůže předloktí u skupiny 60 nemocných SLE a možnosti diagnostické aplikace této metody. Prakt. Lékař., 1995, 75, p. 559–563.
32. VODEGEL, R. M., JONKMAN, M. F., PAS, H. H., DE JONG, M. C. U-serrated immunodeposition pattern differentiates type VII collagen targeting bullous diseases from other subepidermal bullous autoimmune diseases. Br. J. Dermatol., 2004, 151, p. 112–118.
Labels
Dermatology & STDs Paediatric dermatology & STDsArticle was published in
Czech-Slovak Dermatology
2011 Issue 4
Most read in this issue
- Red Sea Coral Contact Dermatitis
- Immunofluorescence in Dermatology
- Psoriasis-like Skin Reactions during TNF-α Blockers Therapy
- Our Experience with Ustekinumab for the Treatment of Psoriasis