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The Follow-up of Patients with Severe Acne Vulgaris Treated with Systemic Isotretinoin


Authors: Z. Nevoralová
Authors‘ workplace: Kožní oddělení, Nemocnice v Jihlavě, p. o., prim. MUDr. Štefan Dubáň
Published in: Čes-slov Derm, 85, 2010, No. 4, p. 198-208
Category: Clinical and laboratory Research

Overview

The aim of the follow-up was to evaluate safety of the treatment, the treatment possibilities in patients with other concomitant diseases and possibility of physical load in treated sportsmen. Following parameters were analyzed: sex and age, localization and type of acne, concomitant diseases, signs of depression and sport activities before treatment; all side effects including laboratory abnormalities, control of concomitant diseases, signs of depression and sport activities during the treatment. Finally, the therapeutic effect was evaluated. The total number of treated and followed patients was 100. Concomitant diseases and laboratory abnormalities before treament were present in 51 % of patients. Intensive sports activities were mentioned by 51 % of males and 10 % of females. Only mild side effects were observed during the treatment. In addition to previously known adverse effects, constipation and lower extremities cramps were newly recorded. No case of depression caused by isotretinoin was observed. Treatment results were excellent in 97 % of cases. The follow-up showed high efficacy and safety of isotretinoin. The treatment was successful also in patients with concomitant internal diseases and laboratory abnormalities. Adequate sports activities during therapy did not influenced the treatment efficacy and safety.

Key words:
acne – systemic isotretinoin – side effects


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