Modified Intravenous Administration of Immunoglobulins in a Female Patientwith the Diagnosis of Pemphigus Vulgaris

Overview

The author describes a 60-year-old woman with the diagnosis of pemphigus vulgaris. The patientcontracted the disease at the age of 56 years. Systemic therapy with Prednisone and immunosup-pressive preparations (Methotrexate, Imuran) brought only temporary relief. After remission alwaysa new exacerbation of the disease followed. After administration of adjuvant treatment with concen-trated human polyvalent IgG - Endobulin i.v. in a total dose of 20 g a marked and rapid improvementof the skin and mucosal manifestations occurred. The patient is now in remission since November1997, at present she is treated with Prednisone 15 mg p.o. per day and Imuran 50 mg p.o. per day.

Key words:
pemphigus vulgaris - intravenous immunoglobulins - adjuvant therapy