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IL-40 – a new cytokine in the pathogenesis of rheumatic diseases

Czech version

Authors: L. Andres Cerezo;  A. Navrátilová;  L. Šenolt
Authors‘ workplace: Revmatologický ústav Praha a 1. LF UK, Praha
Published in: Čes. Revmatol., 30, 2022, No. 2, p. 74-79.
Category: Review Article

Overview

IL-40 is a recently described cytokine associated with malignancies and autoimmune rheumatic diseases. It is mainly produced by immune cells, in particular by activated B lymphocytes and neutrophils. Local and systemic up-regulation of IL-40 was documented in several rheumatic diseases. Levels of IL-40 are elevated in the serum and in the synovial fluid of RA patients and correlate with neutrophil activation and the levels of autoantibodies. Serum IL-40 decreases following different therapies in RA and participates in the regulation of inflammation and tissue remodeling via activation of neutrophils and synovial fibroblasts. Increased expression of IL-40 was also demonstrated in the serum and the salivary glands of patients with Sjögren’s syndrome. Based on the recent data, IL-40 is a multifunctional cytokine implicated in the pathogenesis of autoimmune inflammatory diseases.

Keywords:

Systemic lupus erythematosus – IL-40, rheumatoid arthritis – Sjögren’s syndrome

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Labels
Dermatology & STDs Paediatric rheumatology Rheumatology
Editorial
Doc. MUDr. Jaroslav Hrba, CSc.
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Czech Rheumatology

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2022 Issue 2
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