Polymyalgia rheumatica – is the biological therapy effective?

Czech version

Authors: A. Pavelková
Authors‘ workplace: Revmatologický ústav, Praha
Published in: Čes. Revmatol., 21, 2013, No. 4, p. 183-188.
Category: Rewiev

Overview

Both polymyalgia rheumatica (PMR) and giant-cell arteritis (temporal arteritis, TA) relatively often affect people in old age, have an acute course and cause significant functional impairment. Manifestations of PMR can often resemble those of rheumatoid arthritis (RA). Thus, to differentiate these conditions may be uneasy. In terms of treatment, RA can be treated with chemical agents, disease modifying antirheumatic drugs and glucocorticoids as well as biological agents.Whereas in PMR, glucocorticoid therapy, associated with the side effect burden, is still the only successful treatment. The use of immunosuppressive therapy appears to be effective in patients with diminished response to glucocorticoids or an inability to use the adequate doses. Considering some common etiopathogenetic mechanisms of these two conditions the efficacy of disease modifying chemical and biological agents of rheumatoid arthritis has also been investigated in polymyalgia rheumatica.

Key words:
Polymyalgia rheumatica, biological therapy, glucocorticoids, anti-TNF therapy

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Labels

Dermatology & STDs Paediatric rheumatology Rheumatology

Circulating Heat Shock Protein 90 (HSP90) in patients with rheumatoid arthritis and axial spondylarthritis

Regulatory T cells as a tool in modulation of immune system

Article was published in

Czech Rheumatology

2013 Issue 4