Primary cilia of connective tissue cells

Czech version

Authors: J. Dvořák ¹; Z. Dvořák ²; V. Sitorová ³; Nikolov Dh ³; J. Mokrý ⁴; I. Richter ^5,6; S. Filip ¹; A. Ryška ³; J. Petera ¹
Authors‘ workplace: Klinika onkologie a radioterapie LFUK a FN Hradec Králové, 2ARTHROMED, s. r. o., Pardubice, 3Fingerlandův ústav patologie LFUK a FN Hradec Králové, 4Ústav histologie a embryologie LFUK Hradec Králové, 5Oddělení klinické onkologie, Krajská nemocnice Libere ¹
Published in: Čes. Revmatol., 20, 2012, No. 4, p. 170-174.
Category: Overview Reports

Overview

The primary cilium is a sensory, solitary, non-motile microtubule-based structure protruding in the quiescent phase of the cell cycle from the surface of the majority of human cells, including mesenchymal stem cells, osteoblasts, osteocytes, chondroblasts, chondrocytes, fibroblasts, fibrocytes, chondrocytes of osteoarthritic cartillage, tumor cells of benign and malignant tumors of connective tissue, including enchondroma, osteochondroma, osteosarcoma, chondrosarcoma and Ewing bone sarcoma. Primary cilium is formed from the mother centriole. The aim of this paper is to provide a review of the current knowledge on the primary cilia in connective tissue cells.

Key words:
primary cilia, epiphyseal plate, bone tumors, osteoarthritis

Sources

1. Zimmermann KW. Beitrage zur kenntniss einiger drusen und epithelien. Arch Mikrosk Anat 1898; 52: 552-706.

2. Tonna EA, Lampen NM. Electron microscopy of aging skeletal cells. I. Centrioles and solitary cilia. J Gerontol 1972; 27 (3): 316-324.

3. Whitfield JF. Primary cilium—is it an osteocyte’s strain-sensing flowmeter? J Cell Biochem 2003; 89 (2): 233-237.

4. Sorokin SP. Reconstructions of centriole formation and ciliogenesis in mammalian lungs. J Cell Sci 1968; 3 (2): 207-230.

5. Plotnikova OV, Golemis EA, Pugacheva EN. Cell cycle-dependent ciliogenesis and cancer. Cancer Res 2008; 68 (7): 2058-2061.

6. Dvořák J, Sitorová V, Hadži Nikolov D, Mokrý J, Richter I, Filip S, et al. Primary cilium - antenna-like structure on the surface of most mammalian cell types. J Phys: Conf Ser 2011; 329: 012022.

7. Marshall WF, Nonaka S. Cilia: tuning in to the cell’s antenna. Curr Biol 2006; 16 (15): R604-614.

8. Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA. HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 2007; 129 (7): 1351- -136.

9. Dvořák J, Sitorová V, Hadži Nikolov D, Mokrý J, Richter I, Filip S, et al. Primární řasinky buněk kardiovaskulárního aparátu. Vnitřní lékařství. in press.

10. Michaud EJ, Yoder BK. The primary cilium in cell signaling and cancer. Cancer Res 2006; 66 (13): 6463-6467.

11. Stephan A, Vaughan S, Shaw MK, Gull K, McKean PG. An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport. Traffic 2007; 8 (10): 1323-2330.

12. Kozminski KG, Johnson KA, Forscher P, Rosenbaum JL. A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Natl Acad Sci USA 1993; 90 (12): 5519- -5523.

13. Scholey JM. Intraflagellar transport motors in cilia: moving along the cell’s antenna. J Cell Biol 2008; 180 (1): 23-29.

14. Rosenbaum JL, Witman GB. Intraflagellar transport. Nat Rev Mol Cell Biol 2002; 3 (11): 813-825.

15. Dvořák J, Sitorová V, Hadži Nikolov D, Mokrý J, Richter I, Filip S, et al. Primární řasinky a jejich biologické funkce. Onkologie 2011; 5 (4): 234-238.

16. Tummala P, Arnsdorf EJ, Jacobs CR. The Role of Primary cilia in mesenchymal stem cell differentiation: A Pivotal Switch in Guiding Lineage Commitment. Cell Mol Bioeng 2010; 3 (3): 207-212.

17. Donnelly E, Ascenzi MG, Farnum C. Primary cilia are highly oriented with respect to collagen direction and long axis of extensor tendon. J Orthop Res 2010; 28 (1): 77-82.

18. Anderson CT, Castillo AB, Brugmann SA, Helms JA, Jacobs CR, Stearns T. Primary cilia: cellular sensors for the skeleton. Anat Rec (Hoboken) 2008; 291 (9): 1074-1078.

19. Temiyasathit S, Jacobs CR. Osteocyte primary cilium and its role in bone mechanotransduction. Ann NY Acad Sci 2010; 1192: 422-428.

20. Haycraft CJ, Serra R. Cilia involvement in patterning and maintenance of the skeleton. Curr Top Dev Biol 2008; 85: 303-332.

21. Malone AM, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proc Natl Acad Sci USA 2007; 104 (33): 13325-13330.

22. Turco AE, Padovani EM, Chiaffoni GP, Peissel B, Rossetti S, Marcolongo A, et al. Molecular genetic diagnosis of autosomal dominant polycystic kidney disease in a newborn with bilateral cystic kidneys detected prenatally and multiple skeletal malformations. J Med Genet 1993; 30 (5): 419-422.

23. Ansley SJ, Badano JL, Blacque OE, Hill J, Hoskins BE, Leitch CC, et al. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature 2003; 425 (6958): 628-633.

24. Tobin JL, Di Franco M, Eichers E, May-Simera H, Garcia M, Yan J, et al. Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung’s disease in Bardet-Biedl syndrome. Proc Natl Acad Sci USA 2008; 105 (18): 6714-6719.

25. Ruiz-Perez VL, Blair HJ, Rodriguez-Andres ME, Blanco MJ, Wilson A, Liu YN, et al. Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia. Development 2007; 134 (16): 2903-2912.

26. Beales PL, Bland E, Tobin JL, Bacchelli C, Tuysuz B, Hill J, et al. IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nat Genet 2007; 39 (6): 727-729.

27. Delous M, Baala L, Salomon R, Laclef C, Vierkotten J, Tory K, et al. The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome. Nat Genet 2007; 39 (7): 875-881.

28. Perrault I, Saunier S, Hanein S, Filhol E, Bizet AA, Collins F, et al. Mainzer-Saldino syndrome is a ciliopathy caused by IFT140 mutations. Am J Hum Genet 2012; 90 (5): 864-870.

29. Kyttälä M, Tallila J, Salonen R, Kopra O, Kohlschmidt N, Paavola-Sakki P, et al. MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome. Nat Genet 2006; 38 (2): 155-157.

30. Ferrante MI, Zullo A, Barra A, Bimonte S, Messaddeq N, Studer M, et al. Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet 2006; 38 (1): 112-117.

31. Donnelly E, Williams R, Farnum C. The primary cilium of connective tissue cells: imaging by multiphoton microscopy. Anat Rec (Hoboken) 2008; 291 (9): 1062-1073.

32. Poole CA, Jensen CG, Snyder JA, Gray CG, Hermanutz VL, Wheatley DN. Confocal analysis of primary cilia structure and colocalization with the Golgi apparatus in chondrocytes and aortic smooth muscle cells. Cell Biol Int 1997; 21 (8): 483-494.

33. Lüllmann-Rauch R: Histologie. Grada Publishing a.s. 2012; překlad 3. vydání, 556 s.

34. de Andrea CE, Wiweger M, Prins F, Bovée JV, Romeo S, Hogendoorn PC. Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma. Lab Invest 2010; 90 (7): 1091-1101.

35. Song B, Haycraft CJ, Seo HS, Yoder BK, Serra R. Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol 2007; 305 (1): 202-216.

36. McGlashan SR, Haycraft CJ, Jensen CG, Yoder BK, Poole CA. Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polaris. Matrix Biol 2007; 26 (4): 234-246.

37. Whitfield JF. The solitary (primary) cilium - a mechanosensory toggle switch in bone and cartilage cells. Cell Signal 2008; 20 (6): 1019-1024.

38. Ganev GG. Pathological significance of cilia and centrioles in bone and soft tissue tumors. J Orthop Sci 1997; 2 (3): 137--145.

39. Kouri JB, Argüello C, Luna J, Mena R. Use of microscopical techniques in the study of human chondrocytes from osteoarthritic cartilage: an overview. Microsc Res Tech 1998; 40 (1): 22-36.

40. Capín-Gutiérrez N, Talamás-Rohana P, González-Robles A, Lavalle-Montalvo C, Kourí JB. Cytoskeleton disruption in chondrocytes from a rat osteoarthrosic (OA) -induced model: its potential role in OA pathogenesis. Histol Histopathol 2004; 19 (4): 1125-1132.

41. McGlashan SR, Cluett EC, Jensen CG, Poole CA. Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters. Dev Dyn 2008; 237 (8): 2013-2020.

42. McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S. Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biol Int 2010; 34 (5): 441-446.

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Article was published in

Czech Rheumatology

2012 Issue 4