How to regard structural progression in biological therapy?
Authors:
L. Šenolt
Authors‘ workplace:
Revmatologický ústav, Praha
Published in:
Čes. Revmatol., 19, 2011, No. 2, p. 77-79.
Category:
Posts from Congress
Overview
Structural progression of rheumatoid arthritis manifests as joint space narrowing and development of bone erosions on X-ray images. On conventional therapy structural progression is a manifestation of disease activity, and is usually directly proportional to long-term functional disability. During the first years of the disease irreversible joint involvement often develops. Structural progression occasionally occurs even in patients in clinical remission. Biological therapy, on the other hand, can completely suppress radiographic progression even if certain signs of inflammatory activity are present. Thus, in the assessment of efficacy of biological therapy we have to consider the dissociation between clinical and radiographic findings. Bone reparation has been described in rare cases. In patients treated with biological therapy a low disease activity is acceptable, however, on treatment with synthetic agents, maximum reduction of synovitis and absence of clinically detectable form of the disease should be the therapeutic aim.
Key words:
biological therapy, radiographic progression, remission, inflammatory activity, rheumatoid arthritis
Sources
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Dermatology & STDs Paediatric rheumatology RheumatologyArticle was published in
Czech Rheumatology
2011 Issue 2
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