#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

New potential biomarkers for preeclampsia prediction


Authors: S. Laššáková;  M. Korabečná
Authors‘ workplace: Ústav biologie a lékařské genetiky 1. LF UK a VFN, Praha, přednosta prof. MUDr. O. Šeda, Ph. D.
Published in: Ceska Gynekol 2018; 83(6): 458-463
Category:

Overview

Objective:

The review of recent literature performed with the goal to find novel biomarkers which would be able in combination with actual approaches to contribute to early pre-eclampsia (PE) detection. Attention has been paid namely to biomarkers which are detectable by methodologies of molecular genetics – microRNA (miRNA), long non-coding RNA (lncRNA) and alterations in methylation status of gene promoters with activities playing key roles in PE development.

Design:

Review.

Setting:

Department of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague.

Methods:

Review of articles in PubMed database published till March 2018.

Results:

In patients who developed PE, elevated levels of miR-210, miR-155, miR-16 and miR-181a were repeatedly detected. Lower values than in control subjects were found in miR-223. Exosomes represent one of the main sources of microRNA in blood – they may originate from placenta and also from blood cells themselves.

Among lncRNAs at the level of placenta tissue, the following molecules for further study were selected: LOC391533, LOC284100, CEACAMP8, RPAIN, SPRY4-IT 1 and lncRNA Uc.187 with elevated expression and MEG3, STOX2-IT3, lncRNA-ATB and MALAT-1 with decreased expression.

Alterations in promoter methylation were found also in placental tissue for examples in genes HLA-G, MTHFR, HERVWE 1, GNA12 or SERPINA3.

Conclusion:

For all above mentioned potential biomarkers, it was possible to find the functional links to the complex process of pathogenesis of PE. With regard to the practical use, miR-210 transported in exosomes and having elevated levels in PE patients seems to be most suitable for potential widening of the recent palette of biomarkers.

Keywords

pre-eclampsia, biomarkers, microRNA, long non-coding RNA, promoter methylation


Sources

1. Anderson, UD., Olsson, MG., Kristensen, KH., et al. Review: Biochemical markers to predict preeclampsia. Placenta, 33, Suppl. A, Trophoblast Res, 2012, 26, p. S42–S47.

2. Anton, L., Olarerin-George, AO., Schwartz, N., et al. miR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia. Am J Pathol, 2013, 183, 5, p. 1437–1445.

3. Baek, D., Villén, J., Shin, C., et al. The impact of microRNAs on protein output. Nature, 2008, 455 7209, p. 64–71.

4. Beilke, S., Oswald, F., Genze, F., et al. The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Oncogene, 2010, 29, p. 4058–4067.

5. Cao, C., Li, J., Li, J., et al. Long Non-Coding RNA Uc.187 is upregulated in preeclampsia and modulates proliferation, apoptosis, and invasion of htr-8/svneo trophoblast cells. J Cell Biochem, 2016, 9999, p. 1–9.

6. Cech, TR., Steitz, JA. The noncoding RNA revolution – trashing old rules to forge new ones. Cell, 2014, 157, p. 77–94.

7. Daia, Y., Qiua, Z., Diao, Z., et al. MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1. Placenta, 2012, 33, p. 824–829.

8. Ge, J., Wang, J., Zhang, F., et al. Correlation between MTHFR gene methylation and pre-eclampsia, and its clinical significance. Genet Mol Res, 2015, 14, 3, p. 8021–8028.

9. He, X., He, Y., Xi, B., et al. IncRNAs expression in preeclampsia placenta reveals the potential role of lncRNAs contributing to preeclampsia pathogenesis. PLoS ONE, 2013, 8, 11, p. e81437.

10. Hromadnikova, I. Extracellular nucleic acids in maternal circulation as potential biomarkers for placental insufficiency. DNA Cell Biol, 2012, 31, 7, p. 1221–1232.

11. Hromadnikova, I., Kotlabova, K., Doucha, J., et al. Extracellular chromosome 21-derived microRNA in maternal circulation: evaluation of their diagnostic potential for screening of Down syndrome. Ces Gynek, 2012, 77, 5, p. 395–402.

12. Hromadnikova, I., Kotlabova, K., Jirasek, JE., et al. Detection of placenta-specific microRNAs in maternal circulation. Ces Gynek, 2010, 75, 3, s. 252–256.

13. http://www.uzis.cz/publikace/rodicka-novorozenec-2013 s. 70.

14. Huppertz, B. Placental origins of preeclampsia challenging the current hypothesis. Hypertension, 2008, 51, p. 970–975.

15. Huang, Q., Li, J., Wang, F., et al. Syncytin-1 modulates placental trophoblast cell proliferation by promoting G1/S transition. Cell Signal, 2013, 25, 4, p. 1027–1035.

16. Huang, X., Ding, L., Bennewith, K., et al. Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell, 2009, 35, 6, p. 856–867.

17. Chelbi, ST., Mondon, F., Jammes, H., et al. Expressional and epigenetic alterations of placental serine protease inhibitors serpina3 is a potential marker of preeclampsia. Hypertension, 2007, 49, p. 76–83.

18. Chen, D., Wang, W. Human placental microRNAs and preeclampsia. Biol Reprod, 2013, 88, 5, 130, p. 1–11.

19. Chen, H., Meng, T., Liu, X., et al. Long non-coding RNA MALAT-1 is downregulated in preeclampsia and regulates proliferation, apoptosis, migration and invasion of JEG-3 trophoblast cells. Int J Clin Exp Pathol, 2015, 8, 10, p. 12718–12727.

20. Chodroff, RA., Goodstadt, L., Sirey, TM., et al. Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol, 2010, 11, R72, p. 1–16.

21. Jia, R., Zhang, X., Hu, P., et al. Screening for differential methylation status in human placenta in preeclampsia using a CpG island plus promoter microarray. Int J Mol Med, 2012, 30, p. 133–141.

22. Lee, D., Romero, R., Kim, J., et al. miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines. Am J Pathol, 2011, 179, 2, p. 590–602.

23. Li, X., Li, C., Dong, X., Gou, W. MicroRNA-155 inhibits migration of trophoblast cells and contributes to the pathogenesis of severe preeclampsia by regulating endothelial nitric oxide synthase. Mol Med Rep, 2014, 10, p. 550–554.

24. Lin, S., Leonard, D., Co, MAM., et al. Pre-eclampsia has an adverse impact on maternal and fetal health. Transl Res, 2015, 165, 4, p. 449–463.

25. Liu, L., Wang, Y., Fan, H., et al. MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells. Stem Cells, 2012, 30, p. 1756–1770.

26. Liu, X., Chen, H., Kong, W., et al. Down-regulated long non-coding RNA-ATB in preeclampsia and its effect on suppressing migration, proliferation, and tube formation of trophoblast cells. Placenta, 2017, 49, p. 80–87.

27. Luo, R., Shao, X., Xu, P., et al. MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1. Hypertension, 2014, 64, p. 839–845.

28. Luo, R., Wang, Y., Xu, P., et al. Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. Sci Rep, 2016, 6, p. 19588–19599.

29. Magee, LA., Pels, A., Helewa, M., et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can, 2014, 36, p. 416–441.

30. McKiernan, PJ., Molloy, K., Cryan, SA., et al. Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium. Int J Biochem Cell Biol, 2014, 52, p. 184–191.

31. Muralimanoharan, S., Maloyan, A., Mele, J., et al. Mir-210 modulates mitochondrial respiration in placenta with preeclampsia. Placenta, 2012, 33, 10, p. 816–823.

32. Oudejans, CMB., Poutsma, A., Michel, OJ., et al. Noncoding RNA-regulated gain-of-function of STOX2 in Finnish pre-eclamptic families. Sci Rep, 2016, 6, p. 32129–32139.

33. Pillay, P., Moodley, K., Moodley, J., et al. Placenta-derived exosomes: potential biomarkers of preeclampsia. Int J Nanomedicine, 2017, 12, p. 8009–8023.

34. Pineles, BL, Romero, R., Montenegro, D., et al. Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia. Am J Obstet Gynecol, 2007, 196, 261, p. 261.e1– 261.e6.

35. Poon, LC., Nicolaides, KH. First-trimester maternal factors and biomarker screening for preeclampsia. Prenat Diagn, 2014, 34, p. 618–627.

36. Radulescu, C., Bacârea, A., Hutanu, A., et al. Placental growth factor, soluble fms-like tyrosine kinase 1, soluble endoglin, IL-6, and IL-16 as biomarkers in preeclampsia. Mediators Inflamm, 2016, 2016, p. 3027363–3027341.

37. Roberts, JM., Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet, 2001, 357, p. 53–56.

38. Salomon, C., Guanzon, D., Scholz-Romero, K. Placental exosomes as early biomarker of preeclampsia: potential role of exosomal microRNAs across gestation. J Clin Endocrinol Metab, 2017, 102, p. 3182–3194.

39. Sandrim, VC., Eleuterio, N., Pilan, E., et al. Plasma levels of increased miR-195-5p correlates with the sFLT-1 levels in preeclampsia. Hypertens Pregnancy, 2016, 35, 2, p. 150–158.

40. Song, X., Rui, C., Meng, L., et al. Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q. Oncotarget, 2017, 8, p. 7637–7646.

41. Surani, MA. Reprogramming of genome function through epigenetic inheritance. Nature, 2001, 414, p. 122–128.

42. Tang, Y., Liu, H., Li, H., et al. Hypermethylation of the HLA-G promoter is associated with preeclampsia. Mol Hum Reprod, 2015, 21, 9, p. 736–744.

43. Wang, Y., Fan1, H., Zhao, G., et al. miR-16 inhibits the proliferation and angiogenesis-regulating potential of mesenchymal stem cells in severe pre-eclampsia. FEBS J, 2012, 279, p. 4510–4524.

44. White, WM., Sun, Z., Borowski, KS., et al. Preeclampsia/eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery. Hypertens Pregnancy, 2016, 35, 3, p. 394–404.

45. Xiang, Y., Zhang, X., Li, Q., et al. Promoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese population. Mol Hum Reprod, 2013, 19, 3, p. 153–159.

46. Yan, YH., Yi, P., Zheng, YR., et al. Screening for preeclampsia pathogenesis related genes. Eur Rev Med Pharmacol Sci, 2013, 17, p. 3083–3094.

47. Ye, W., Shen, L., Xiong, Y., et al. Preeclampsia is associated with decreased methylation of the GNA12 promoter. Ann Hum Genet, 2016, 80, p. 7–10.

48. Yuen, RKC., Penaherrera, MS., Dadelszen, P. von, et al. DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia. Eur J Hum Genet, 2010, 18, p. 1006–1012.

49. Yeung, KR., Chiu, CL., Pidsley, R., et al. DNA methylation profiles in preeclampsia and healthy control placentas. Am J Physiol Heart Circ Physiol, 2016, 310 p. H1295–H1303.

50. Zhang, C. MicroRNomics: a newly emerging approach for disease biology. Physiol Genomics, 2008, 33, p. 139–147.

51. Zhang, Y., Diao, Z., Su, L., et al. MicroRNA-155 contributes to preeclampsia by down-regulating CYR61. Am J Obstet, 2010, 202, p. 466.e1–466.e7.

52. Zhang, Y., Fei, M., Xue, G., et al. Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease. J Cell Mol Med, 2012, 16, 2, p. 249–259.

53. Zhang, Y., Zou, Y., Wang, W., et al. Down-regulated long non-coding RNA MEG3 and its effect on promoting apoptosis and suppressing migration of trophoblast cells. J Cell Biochem, 2015, 116, p. 542–550.

54. Zuo, Q., Huang, S., Zou, Y., et al. The lncRNA SPRY4-IT1 modulates trophoblast cell invasion and migration by affecting the epithelial-mesenchymal transition. Sci Rep, 2016, 6, p. 37183–37196.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#