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Thrombophilic mutation by women with serious pregnancy complications


Authors: B. Vavřinková 1;  T. Binder 1;  I. Hadačová 2;  I. Hrachovinová 3;  P. Salaj 3;  Martin Hruda 1
Authors‘ workplace: Gynekologicko-porodnická klinika 2. LF UK a FN Motol, Praha, přednosta prof. L. Rob, CSc. 1;  Oddělení klinické hematologie FN Motol, Praha, prim. I. Hochová 2;  Ústav hematologie a krevní transfúze, Praha, ředitel prof. MUDr. M. Trněný, CSc. 3
Published in: Ceska Gynekol 2012; 77(2): 171-174
Category: Original Article

Overview

Objective:
The purpose of this study was to determine whether maternal or fetal genotype frequencies of the inherited thrombophilic gene mutation (F V Leiden, F II) are altered in adverse pregnancy outcomes – severe preeclampsia, IUGR, abruption of placenta and stillbirth.

Design of the study:
Retrospective study.

Setting:
Department of Gynecology and Obstetrics of the Teaching Hospital and the 2nd Medical Faculty of the Charles University in Prague.

Methods:
We studied 232 women who had pregnancy complications. All women were tested postpartum for mutation of factor V Leiden and G20210A prothrombine gene. At the same time were tested the newborns of those women.

Results:
In the group of women with preeklampsia (n=141) we have demonstrated 5 women with mutation encoding for F V, 5 women with mutation encoding for F II and 1 combination of both. In the group of IUGR 2 women with mutation F V, 1 with mutation F II a 1 combination of both were found. In women after stillbirth occure two mutation of F V, one mutation of F II and one combination of both. In the group with abruptio of placenta was 1 case of mutation F V and 3 cases of mutation F II. When we tested a newborn we found 4 cases of mutation F V and 3 cases of F II in the group with preeclampsia, 4 cases of mutation F V 3 cases od mutation of F II in the group with IUGR, no case in the group with abruptio of placenta and 1 case in a death fetus. There was no assotiation between any severe pregnancy complications and any of the maternal or fetal inherited thrombophilia.

Conclusion:
Factor V Leiden and prothrombin gene mutations did not seem play a significant role in adverse pregnancy outcome in our population.

Key words:
thrombophilia, mutation, Leiden, prothrombin, preeclampsia, IUGR, abruption, stillbirth.


Sources

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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Czech Gynaecology

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2012 Issue 2

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