Risk factors for recurrent disease in borderline ovarian tumors

Czech version

Authors: P. Líbalová ¹; Z. Vernerová ²; L. Hubičková-Heringová ³; D. Pintérová ⁴; K. Tikovský ¹; M. Kubecová ⁵; B. Svoboda ¹
Authors‘ workplace: Gynekologicko-porodnická klinika 3. LF UK a FNKV, přednosta doc. MUDr. E. Kučera, CSc. ¹; Ústav patologie 3. LF UK a FNKV, přednosta prof. MUDr. V. Mandys, CSc. ²; Ústav histologie a embryologie 3. LF UK a FNKV, přednosta prof. MUDr. J. Stingl, CSc. ³; Gynekologicko-porodnická klinika, oddělení nádorové biologie 3. LF UK a FNKV, přednosta doc. MUDr. E. Kučera, CSc. ⁴; Radioterapeutická a onkologická klinika 3. LF UK a FNKV, přednosta doc. MUDr. M. Kubecová, Ph. D. ⁵
Published in: Ceska Gynekol 2012; 77(1): 31-35
Category: Original Article

Overview

Objective:
To evaluate risk factors for development of recurrent disease in borderline ovarian tumors.

Design:
Retrospective study of 10-years single institution population.

Setting:
Dept. of Gynecology and Obstetrics, 3^rd Medical Faculty of Charles University in Prague.

Method:
59 consecutive cases of borderline ovarian tumors (BOT) were analyzed for age, histopathological type, DNA ploidy, stage, presence of invasive and non-invasive peritoneal implants, type of surgical procedure, residual disease, adjuvant therapy, recurrence and long-time prognosis of the patients.

Results:
Median follow-up was 47 months (range 1-144). There were 5 (8.5%) patients with DNA aneuploid tumors in the study group; 4 of them were younger than 50 years, 4 of them were early stage serous BOT; no one recur so far. No death of disease was described in the whole study group; only 2 patients (3.4%) developed recurrent disease – both were young patients after conservative surgery for serous diploid stage I/II BOT. Conservative surgery was the only significant factor for recurrence in univariate analysis (p = 0.0159) in our setting.

Conclusion:
DNA ploidy was not proved to be prognostic factor in borderline ovarian tumors in our study group. The only significant risk factor for development of recurrent disease was conservative surgery, with no influence on overall survival.

Key words:
borderline ovarian tumor, recurrence, risk factors, DNA ploidy, conservative surgery.

Sources

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Article was published in

Czech Gynaecology

2012 Issue 1