Thrombin generation test at physiological and risk gravidity

Czech version

Authors: V. Lattová ¹; M. Procházka ¹; J. Úlehlová ²
Authors‘ workplace: Porodnicko-gynekologická klinika FN, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. ¹; Hemato-onkologická klinika FN, Olomouc, přednosta prof. MUDr. K. Indrák, DrSc. ²
Published in: Ceska Gynekol 2011; 76(5): 367-370

Overview

Generation of thrombin is pivotal step of hemostasis, according to in vitro experiments, thrombin generation occurs in 2 phases. Initially small amount of thrombin is produced after activation of factor X by complex TF / FVIIa. Thrombin multiplies coagulation by activation of platelets, F V a F VIII. Complex of TF / FVIIa activates also F VIII a, F IX, F VIII and FIXa and its binding to surface of platelets, which activates F X and products quantity of thrombin and leads formation of fibrin and finaly to triggering clotting.

Design:
Review.

Setting:
Department of Obstetrics and Gynecology, University Hospital Olomouc.

Key words:
thrombin generation test, gravidity, coagulation.

Sources

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